Bioorganic & Medicinal Chemistry Letters 2006-12-01

Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.

Tomoko Fukuuchi, Katsumi Doh-Ura, Shin'ichi Yoshihara, Shigeru Ohta

Index: Bioorg. Med. Chem. Lett. 16 , 5982-7, (2006)

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Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.