1,6-DINITROPYRENE
1,6-DINITROPYRENE structure
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Common Name | 1,6-DINITROPYRENE | ||
|---|---|---|---|---|
| CAS Number | 42397-64-8 | Molecular Weight | 292.246 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 515.2±30.0 °C at 760 mmHg | |
| Molecular Formula | C16H8N2O4 | Melting Point | >300ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 261.6±17.4 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.
Mutat. Res. 538(1-2) , 121-31, (2003) To clarify the mutagenic potential of surface soil in the Kinki region of Japan, particularly in Osaka and neighboring cities, 62 surface soil samples were collected and their organic extracts were examined by the Ames/Salmonella assay. All of the samples wer... |
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High-performance liquid chromatography-fluorescence determination of dinitropyrenes in soil after column chromatographic clean-up and on-line reduction.
J. Chromatogr. A. 839(1-2) , 41-8, (1999) In order to quantify 1,3-dinitropyrene (DNP), 1,6-DNP and 1,8-DNP in soil, we developed an efficient clean-up procedure and a sensitive determination method using fluorescence detection. DNP isomers were efficiently cleaned by three stages of fractionation, i... |
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Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
Mutat. Res. 472(1-2) , 129-38, (2000) The genotoxicities of four samples of diesel exhaust particle (DEP) extracts (DEPE) and nine nitroarenes found in DEPE were investigated after activation catalyzed by human cytochrome P450 (P450) family 1 enzymes co-expressed with NADPH-cytochrome P450 reduct... |
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Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).
Mutat. Res. 515(1-2) , 73-83, (2002) Dinitropyrenes (DNPs), 1,3-, 1,6- and 1,8-dinitropyrene, are carcinogenic compounds found in diesel engine exhaust. DNPs are strongly mutagenic in the bacterial mutation assay (Ames test), mainly inducing frameshift type mutations. To assess mutagenicity of D... |
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Distributions of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler.
Mutat. Res. 348(2) , 57-61, (1995) Distributions of 1,3-dinitropyrene (1,3-DNP), 1,6-DNP, 1,8-DNP, 1-nitropyrene (1-NP) and mutagenicity in airborne particulates collected in downtown Kanazawa, Japan with an Andersen high-volume air sampler were examined. Mutagenicities of benzene-ethanol extr... |
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Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.
Toxicology 231(2-3) , 159-74, (2007) Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) >> DEPE >> 1,8-dinitropyrene (1,8-DNP). The co... |
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Mutagenic activity of surface soil and quantification of 1,3-, 1,6-, and 1,8-dinitropyrene isomers in soil in Japan.
Chem. Res. Toxicol. 13(4) , 281-6, (2000) To clarify the mutagenic potential of nonagricultural surface soil in Japan, 110 soil samples were collected from five geographically different areas between November 1996 and March 1997, and organic extracts of the soil samples were examined by the Ames/Salm... |
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Identification of 1,6- and 1,8-dinitropyrene isomers as major mutagens in organic extracts of soil from Osaka, Japan.
Chem. Res. Toxicol. 11(12) , 1501-7, (1998) The organic extracts of soil collected at parks in residential areas in Osaka and neighboring cities in the Kansai area, Japan, showed mutagenicity in Salmonella typhimurium strain TA98 in the presence or absence of a mammalian metabolic activation system (S9... |
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Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens.
Mutat. Res. 649(1-2) , 201-12, (2008) To clarify the mutagenic potential of surface soil in residential areas in Kyoto city, surface soil samples were collected twice or three times from 12 sites, and their organic extracts were examined by the Ames/Salmonella assay. Almost all (>92%) samples sho... |
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Comparative mutagenesis of the C8-guanine adducts of 1-nitropyrene and 1,6- and 1,8-dinitropyrene in a CpG repeat sequence. A slipped frameshift intermediate model for dinucleotide deletion.
J. Biol. Chem. 277(47) , 45068-74, (2002) In the Ames Salmonella typhimurium reversion assay 1,6- and 1,8-dinitropyrenes (1,6- and 1,8-DNPs) are much more potent mutagens than 1-nitropyrene (1-NP). Genetic experiments established that certain differences in the metabolism of the DNPs, which in turn r... |