1,6-DINITROPYRENE

Modify Date: 2024-01-08 07:37:53

1,6-DINITROPYRENE structure	Common Name	1,6-DINITROPYRENE
	CAS Number	42397-64-8	Molecular Weight	292.246
	Density	1.6±0.1 g/cm3	Boiling Point	515.2±30.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₈N₂O₄	Melting Point	>300ºC(lit.)
	MSDS	Chinese USA	Flash Point	261.6±17.4 °C
	Symbol	GHS08	Signal Word	Danger

Name	1,6-Dinitropyrene
Synonym	More Synonyms

Density	1.6±0.1 g/cm3
Boiling Point	515.2±30.0 °C at 760 mmHg
Melting Point	>300ºC(lit.)
Molecular Formula	C₁₆H₈N₂O₄
Molecular Weight	292.246
Flash Point	261.6±17.4 °C
Exact Mass	292.048401
PSA	91.64000
LogP	4.63
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.888

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR2455000

CHEMICAL NAME :: Pyrene, 1,6-dinitro-

CAS REGISTRY NUMBER :: 42397-64-8

BEILSTEIN REFERENCE NO. :: 3413178

LAST UPDATED :: 199710

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C16-H8-N2-O4

MOLECULAR WEIGHT :: 292.26

WISWESSER LINE NOTATION :: L666 B6 2AB PJ DNW KNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9206 ug/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrapleural

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 104 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rabbit Lung

DOSE/DURATION :: 2500 ng/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 175,259,1986 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,215,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,215,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,215,1989

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H350
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R45
Safety Phrases	S53;S56
RIDADR	NONH for all modes of transport
RTECS	UR2455000
HS Code	2904209090

Pyrene

CAS#:129-00-0

1,6-DINITROPYRENE

CAS#:42397-64-8

Literature: Hasegawa, Eietsu; Takizawa, Shinya; Seida, Takayuki; Yamaguchi, Akira; Yamaguchi, Naoto; Chiba, Naoki; Takahashi, Tomoya; Ikeda, Hiroshi; Akiyama, Kimio Tetrahedron, 2006 , vol. 62, # 27 p. 6581 - 6588

Pyrene

CAS#:129-00-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Literature: Vollmann et al. Justus Liebigs Annalen der Chemie, 1937 , vol. 531, p. 1,43, 121

aminopyrene

CAS#:1606-67-3

1-Nitropyrene

CAS#:5522-43-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Detail

Literature: Hashimoto, Yuichi; Shudo, Koichi Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1992 - 1994

1,8-DIAMINOPYRENE

CAS#:30269-04-6

1-Nitropyrene

CAS#:5522-43-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Detail

Literature: Hashimoto, Yuichi; Shudo, Koichi Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1992 - 1994

1,6-Pyrenediamine

CAS#:14923-84-3

1-Nitropyrene

CAS#:5522-43-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Detail

Literature: Hashimoto, Yuichi; Shudo, Koichi Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1992 - 1994

1,3-DIAMINOPYRENE

CAS#:92821-64-2

1-Nitropyrene

CAS#:5522-43-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Detail

Literature: Hashimoto, Yuichi; Shudo, Koichi Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1992 - 1994

1-Nitropyrene

CAS#:5522-43-0

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

1,3-Dinitropyrene

CAS#:75321-20-9

Literature: Wang, Huimin; Hasegawa, Kiyoshi; Kagaya, Shigehiro Chemosphere, 1999 , vol. 39, # 11 p. 1923 - 1936

Pyrene

CAS#:129-00-0

acetic acid

CAS#:64-19-7

1,8-DINITROPYRENE

CAS#:42397-65-9

1,6-DINITROPYRENE

CAS#:42397-64-8

Literature: Vollmann et al. Justus Liebigs Annalen der Chemie, 1937 , vol. 531, p. 1,33, 43, 46, 107, 121, 123

Precursor 7
CAS#:129-00-0 Pyrene CAS#:1606-67-3 aminopyrene CAS#:30269-04-6 1,8-DIAMINOPYRENE CAS#:14923-84-3 1,6-Pyrenediamine
CAS#:92821-64-2 1,3-DIAMINOPYRENE CAS#:5522-43-0 1-Nitropyrene CAS#:64-19-7 acetic acid
DownStream 1
CAS#:14923-84-3 1,6-Pyrenediamine

HS Code	2904209090
Summary	2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.

Mutat. Res. 538(1-2) , 121-31, (2003)

To clarify the mutagenic potential of surface soil in the Kinki region of Japan, particularly in Osaka and neighboring cities, 62 surface soil samples were collected and their organic extracts were ex...

High-performance liquid chromatography-fluorescence determination of dinitropyrenes in soil after column chromatographic clean-up and on-line reduction.

J. Chromatogr. A. 839(1-2) , 41-8, (1999)

In order to quantify 1,3-dinitropyrene (DNP), 1,6-DNP and 1,8-DNP in soil, we developed an efficient clean-up procedure and a sensitive determination method using fluorescence detection. DNP isomers w...

Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

Mutat. Res. 472(1-2) , 129-38, (2000)

The genotoxicities of four samples of diesel exhaust particle (DEP) extracts (DEPE) and nine nitroarenes found in DEPE were investigated after activation catalyzed by human cytochrome P450 (P450) fami...

1,6-DINITROPYRENE

MFCD00010494

Pyrene, 1,6-dinitro-

1,6-DINITROPYRENE

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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Synonyms