isoluminol
isoluminol structure
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Common Name | isoluminol | ||
|---|---|---|---|---|
| CAS Number | 3682-14-2 | Molecular Weight | 177.160 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 633ºC at 760mmHg | |
| Molecular Formula | C8H7N3O2 | Melting Point | 300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 336.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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H1-antihistamines and oxidative burst of professional phagocytes.
Neuro Endocrinol. Lett. 30 Suppl 1 , 133-6, (2009) We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level of isolated and stimulated human polymorphonuclear leukocytes.Oxidative burst of isolated human neutrophils was studied by means of l... |
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A new chemiluminescence paradox: selective inhibition of isoluminol-amplified activity in phagocytes by peptides from annexin AI.
Luminescence 23(3) , 139-43, (2008) Chemiluminescence systems enhanced by either isoluminol or luminol in combination with a peroxidase are sensitive methods for the detection of reactive oxygen species (ROS) generated by phagocyte NADPH oxidase. The two amplifying substrates are structurally v... |
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An attempt to design an isoluminol-hydrogen peroxidase-amplified CL that measures intracellularly produced H2O2 in phagocytes: sensitivity for H2O2 is not high enough to allow detection.
Luminescence 22(5) , 507-10, (2007) A technique was designed for the determination of hydrogen peroxide release. We found, however, that the isoluminol-amplified chemiluminescence technique is a suitable tool for measuring secretion of superoxide but not hydrogen peroxide.Copyright 2007 John Wi... |
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Validation of different chemilumigenic substrates for detecting extracellular generation of reactive oxygen species by phagocytes and endothelial cells.
Luminescence 18(5) , 268-73, (2003) Chemiluminescence is a widely used tool to detect extracellular generation of reactive oxygen species (ROS). In the present study we tested four different chemilumigenic substrates (CLS)--luminol, isoluminol, lucigenin and pholasin-to detect extracellular CL ... |
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The combined luminol/isoluminol chemiluminescence method for differentiating between extracellular and intracellular oxidant production by neutrophils.
Redox Rep. 11(3) , 110-6, (2006) To address the question why isoluminol, but not luminol, failed to detect oxidants produced intracellularly, differences between these luminophores were investigated with respect to physicochemical parameters and the character of chemiluminescence signal. Our... |
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Synthesis of novel isoluminol probes and their use in rapid bacterial assays
Bioorg. Med. Chem. Lett. 19(19) , 5722-6, (2009) Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol ( 14) and GluGlu-isoluminol ( 16) probes. Compared to two conventional methods that are widely used, namely nucleic acid probes and polymerase chain reaction (PCR) assays, thes... |
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Differentiating between intra- and extracellular chemiluminescence in diluted whole-blood samples.
Int. J. Lab. Hematol. 34(2) , 136-42, (2012) The differentiation between extra- and intracellular production of reactive oxygen species (ROS) in whole blood was measured by luminol- and isoluminol-enhanced chemiluminescence (CL).Azide (total CL inhibition), azide + horseradish peroxidase (HRP, restoring... |
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Thiols enhance the sensitivity of luminescent assays for non-cross-linked and covalently cross-linked aminophthalhydrazides.
Luminescence 16(4) , 257-62, (2001) Transglutaminases catalyse an acyl-transfer reaction between the gamma-carboxamide of a protein or peptide-bound glutamine (P-CH2-gammaCH2-CO-1NH2) and the primary amino group of mono- or polyamines (R-2NH2), covalently cross-linking the reactants by an isope... |
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Synthesis and characterizations of iso-luminol-functionalized, tadpole-shaped, gold nanomaterials.
Luminescence 28(1) , 7-15, (2013) Iso-luminol functionalized gold nanomaterials were synthesized in high yield by a simple seeding approach, using the chemiluminescent reagent iso-luminol as reductant in the presence of HAuCl(4), AgNO(3) and cetyltrimethylammonium bromide (CTAB). The morpholo... |
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Chemiluminescence assay for tetrahydrobiopterin based on the generation of hydrogen peroxide using isoluminol-microperoxidase in the presence of 1-methoxy PMS.
Luminescence 22(3) , 245-50, (2007) We developed a novel highly sensitive chemiluminescence (CL) method for BH(4). The principle of the proposed method is based on active oxygen formation induced by 1-methoxy-5-methyl phenazinium methyl sulphate (1-methoxy PMS) in the presence of dissolved oxyg... |