Bioorganic & Medicinal Chemistry Letters 2009-01-01

Synthesis of novel isoluminol probes and their use in rapid bacterial assays

Sundar Neelakantan, Iwan Surjawan, Huseyin Karacelik, Clair L. Hicks, Peter A. Crooks, Sundar Neelakantan, Iwan Surjawan, Huseyin Karacelik, Clair L. Hicks, Peter A. Crooks

Index: Bioorg. Med. Chem. Lett. 19(19) , 5722-6, (2009)

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Abstract

Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol ( 14) and GluGlu-isoluminol ( 16) probes. Compared to two conventional methods that are widely used, namely nucleic acid probes and polymerase chain reaction (PCR) assays, these current probe assays may have certain advantages, such as high sensitivity, and short preparation and assay time.