(4-Aminobutyl)phosphonic acid

(4-Aminobutyl)phosphonic acid Structure
(4-Aminobutyl)phosphonic acid structure
Common Name (4-Aminobutyl)phosphonic acid
CAS Number 35622-27-6 Molecular Weight 153.12
Density 1.304g/cm3 Boiling Point 344.2ºC at 760mmHg
Molecular Formula C4H12NO3P Melting Point N/A
MSDS Chinese USA Flash Point 161.9ºC
Symbol GHS07
GHS07
Signal Word Warning

Role of dopamine and GABA in the control of motor activity elicited from the rat nucleus accumbens.

Pharmacol. Biochem. Behav. 38 , 829-835, (1991)

The application of 1.2 and 12.0 micrograms/side of the GABAA receptor agonist 3-aminopropane sulphonic acid bilaterally into the nucleus accumbens (Acb) of rats nonsignificantly depressed locomotor activity as assessed in automated Animex activity cages, whil...

Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists.

Mol. Pharmacol. 43 , 609-625, (1993)

Poly(A)+ RNA from mammalian retina expresses bicuculline/baclofen-insensitive gamma-aminobutyric acid (GABA) receptors in Xenopus oocytes with properties similar to those of homooligomeric GABA rho 1 receptors. The pharmacological profile of these rho-like re...

Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion.

Neuroendocrinology 56 , 687, (1992)

Previous work from our laboratory showed that baclofen could lower serum prolactin (PRL) levels acting at the central nervous system. The present experiments were designed to evaluate whether the gamma-aminobutyric acid B agonist was also effective in inhibit...

Differential effects of phosphonic analogues of GABA on GABA(B) autoreceptors in rat neocortical slices.

Naunyn Schmiedebergs Arch. Pharmacol. 357 , 408-412, (1998)

The effects of five phosphonic derivatives of GABA on the release of [3H]-GABA from rat neocortical slices, preloaded with [3H]-GABA, were investigated. Phaclofen and 4-aminobutylphosphonic acid (4-ABPA) increased the overflow of [3H] evoked by electrical sti...

Evidence for pharmacologically distinct subsets of GABAB receptors.

Brain Res. Bull. 21 , 439-443, (1988)

Activation of GABAB receptors augments neurotransmitter-stimulated cyclic AMP accumulation while inhibiting forskolin-mediated second messenger production. Previous studies have revealed that GABAB receptors are associated with a pertussis toxin sensitive G p...

Pharmacology of the GABAB receptor in amphibian retina.

Brain Res. 660 , 267-274, (1994)

Amacrine and ganglion cells in the amphibian retina contain GABAB, as well as GABAA, receptors. Baclofen, a GABAB agonist, hyperpolarizes the dark membrane potential of these third order neurons and makes their light responses more transient. GABAB receptors ...

Monolayer-directed assembly and magnetic properties of FePt nanoparticles on patterned aluminum oxide.

Int. J. Mol. Sci. 11 , 1162-79, (2010)

FePt nanoparticles (NPs) were assembled on aluminum oxide substrates, and their ferromagnetic properties were studied before and after thermal annealing. For the first time, phosph(on)ates were used as an adsorbate to form self-assembled monolayers (SAMs) on ...

Analysis of gamma-aminobutyric acidB receptor function in the in vitro and in vivo regulation of alpha-melanotropin-stimulating hormone secretion from melanotrope cells of Xenopus laevis.

Endocrinology 132(2) , 674-81, (1993)

The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known...

The utilization of 4-aminobutylphosphonate as sole nitrogen source by a strain of Kluyveromyces fragilis.

FEMS Microbiol. Lett. 184(2) , 237-40, (2000)

A strain of the yeast Kluyveromyces fragilis was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen or carbon. Only 4-aminobutylphosphonate was utilized as sole nitrogen ...