Hydrocortisone acetate
Hydrocortisone acetate structure
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Common Name | Hydrocortisone acetate | ||
|---|---|---|---|---|
| CAS Number | 50-03-3 | Molecular Weight | 404.497 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 576.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C23H32O6 | Melting Point | 223 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 196.2±23.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.
PLoS Negl. Trop. Dis. 8(11) , e3305, (2014) Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for yea... |
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Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus).
Psychoneuroendocrinology 34(8) , 1222-34, (2009) Both acute and chronic stress can impair maternal behavior and increase rates of infant abuse in several species. The mechanisms inducing these effects are unknown, but experimental manipulation of circulating corticosterone levels alters maternal behavior in... |
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Molecular characteristics for solid-state limited solubility.
J. Med. Chem. 51 , 3035-9, (2008) Solubility and solid-state characteristics were determined and multivariate data analysis was used to deduce structural features important for solid-state limited solubility of marketed drugs. Molecules with extended ring structures and large conjugated syste... |
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GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.
Med. Mycol 52(5) , 506-18, (2014) Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles remain unclear. To determine the function of GliA, we disrupted gliA in... |
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S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
Adv. Healthc. Mater. 4(10) , 1484-90, 1423, (2015) A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, i... |
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Determination of log D via automated microfluidic liquid-liquid extraction.
J. Med. Chem. 51 , 5140-2, (2008) A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both met... |
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Antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole.
Cutis. 82(4) , 273-80, (2008) Commercially available topical formulations consisting of iodoquinol 1%-hydrocortisone acetate 2%, ciclopirox 0.77%, and clotrimazole 1%-betamethasone dipropionate 0.5% were assessed for their antimicrobial activity against cultures of Micrococcus luteus, Pro... |
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Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.
PLoS Pathog. 11 , e1004834, (2015) Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key qu... |