Advanced Healthcare Materials 2015-07-15

S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.

Alex Schudel, Timothy Kassis, J Brandon Dixon, Susan N Thomas

Index: Adv. Healthc. Mater. 4(10) , 1484-90, 1423, (2015)

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Abstract

A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.