Journal of medicinal and pharmaceutical chemistry 2008-08-28

Determination of log D via automated microfluidic liquid-liquid extraction.

Muhammad Alimuddin, Daniel Grant, Daryl Bulloch, Noelle Lee, Martin Peacock, Russell Dahl

Index: J. Med. Chem. 51 , 5140-2, (2008)

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Abstract

A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2) = 0.994). The developed methodology is amenable to automation, enabling high-throughput determination of large compound collections.