Hydrocortisone
Hydrocortisone structure
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Common Name | Hydrocortisone | ||
|---|---|---|---|---|
| CAS Number | 50-23-7 | Molecular Weight | 362.460 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 566.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H30O5 | Melting Point | 211-214 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 310.4±26.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Functional consequence of the MET-T1010I polymorphism in breast cancer.
Oncotarget 6(5) , 2604-14, (2015) Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an unc... |
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
PLoS ONE 9(7) , e101824, (2014) Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation of d... |
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MYC is a critical target of FBXW7.
Oncotarget 6(5) , 3292-305, (2015) MYC deregulation is a driver of many human cancers. Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumorigenic phenotype. While direct targeting of MYC is difficul... |
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Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.
PLoS ONE 10(2) , e0118336, (2015) Oncogenic transformation is characterized by morphological changes resulting from alterations in actin dynamics and adhesive activities. Emerging evidence suggests that the protocadherin FAT4 acts as a tumor suppressor in humans, and reduced FAT4 gene express... |
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Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro.
Nutr. Cancer 66(7) , 1257-67, (2014) In this study the potential anticancer effect of 2 flavonoids, myiricetin (MYR) and naringenin (NAR) has been evaluated on an oral squamous cell carcinoma (OSCC) cell line, SCC-25, and HaCaT cells. Both the flavonoids inhibited SCC-25 cell growth, although NA... |
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Flow perfusion co-culture of human mesenchymal stem cells and endothelial cells on biodegradable polymer scaffolds.
Ann. Biomed. Eng. 42(7) , 1381-90, (2014) In this study, we investigated the effect of flow perfusion culture on the mineralization of co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). Osteogenically precultured hMSCs were seeded onto electrospun... |
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Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.
Oncotarget 5(20) , 9710-26, (2014) Diacylglycerol kinase (DGK)α converts diacylglycerol to phosphatidic acid. This lipid kinase sustains survival, migration and invasion of tumor cells, with no effect over untransformed cells, suggesting its potential as a cancer-specific target. Nonetheless t... |
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Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.
Tissue Eng. Part A 21(5-6) , 948-59, (2015) Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) ... |
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Multifactorial analysis of conditional reprogramming of human keratinocytes.
PLoS ONE 10(2) , e0116755, (2015) Co-culture of human primary epithelial cells with irradiated 3T3 fibroblast feeder cells (J2 cells) and the Rho kinase inhibitor Y-27632 (Y) allows for the unrestricted growth of cells of epithelial origin by the process termed conditional reprogramming. To b... |
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Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells.
Arthritis. Res. Ther. 17 , 72, (2015) Type I interferons are pivotal in the activation of autoimmune response in systemic lupus erythematous. However, the pathogenic role of interferon-alpha in patients affected by lupus nephritis remains uncertain. The aim of our study was to investigate the pre... |