3′,5′-Cyclic nucleotide phosphodiesterase
3′,5′-Cyclic nucleotide phosphodiesterase structure
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Common Name | 3′,5′-Cyclic nucleotide phosphodiesterase | ||
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| CAS Number | 9040-59-9 | Molecular Weight | 261.064 | |
| Density | N/A | Boiling Point | 572.9±52.0 °C at 760 mmHg | |
| Molecular Formula | C7H8AsNO5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 253.4±19.1 °C | |
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Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.
Mol. Pharmacol. 84(6) , 787-93, (2013) Tissue fibrosis is characterized by excessive production, deposition, and contraction of the extracellular matrix (ECM). The second messenger cAMP has antifibrotic effects in fibroblasts from several tissues, including cardiac fibroblasts (CFs). Increased cel... |
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Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3).
FASEB J. 27(11) , 4419-28, (2013) The ectoenzyme CD39 suppresses thrombosis and inflammation by suppressing ATP and ADP to AMP. However, mechanisms of CD39 transcriptional and post-translational regulation are not well known. Here we show that CD39 levels are modulated by inhibition of phosph... |
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Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension.
Hypertension 61(3) , 585-92, (2013) Chronic exposure to cold caused pulmonary arterial hypertension (cold-induced pulmonary hypertension [CIPH]) and increased phosphodiesterase-1C (PDE-1C) expression in pulmonary arteries (PAs) in rats. The purpose of this study is to investigate a hypothesis t... |
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Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
FASEB J. 28(2) , 791-801, (2014) Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impair its expression and/or chloride channel function. Here, we provide evidence that type 4 cyclic nucleotide phosphodiester... |
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Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
J. Nat. Prod. 76(3) , 382-7, (2013) Three bioactive compounds were isolated from an organic extract of an ascomycete fungus of the order Chaetothyriales (MSX 47445) using bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Of these, two were benzo... |
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ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Proc. Natl. Acad. Sci. U. S. A. 109(48) , 19691-6, (2012) Mutations affecting ciliary components cause a series of related genetic disorders in humans, including nephronophthisis (NPHP), Joubert syndrome (JBTS), Meckel-Gruber syndrome (MKS), and Bardet-Biedl syndrome (BBS), which are collectively termed "ciliopathie... |
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
J. Biol. Chem. 288(5) , 3477-88, (2013) Insulin resistance, hyperlipidemia, and cardiovascular complications are common dysregulations of metabolic syndrome. Transplant patients treated with immunosuppressant drugs such as cyclosporine A (CsA), an inhibitor of calcineurin phosphatase, frequently de... |
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BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function.
J. Pharmacol. Exp. Ther. 349(1) , 56-65, (2014) Elevation of intracellular cAMP and activation of protein kinase A (PKA) lead to activation of large conductance voltage- and Ca(2+)-activated K(+) (BK) channels, thus attenuation of detrusor smooth muscle (DSM) contractility. In this study, we investigated t... |
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cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland.
Am. J. Physiol. Cell Physiol. 306(4) , C343-53, (2014) The in vitro perfused rectal gland of the dogfish shark (Squalus acanthias) and filter-grown monolayers of primary cultures of shark rectal gland (SRG) epithelial cells were used to analyze the signal transduction pathway by which C-type natriuretic peptide (... |
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Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata.
Org. Lett. 16(1) , 282-5, (2014) Selaginpulvilins A-D (1-4), four new phenols with an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton, together with four known selaginellins (5-8) were isolated from Selaginella pulvinata. Their structures were elucidated by spectroscopic an... |