Daltroban
Daltroban structure
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Common Name | Daltroban | ||
|---|---|---|---|---|
| CAS Number | 79094-20-5 | Molecular Weight | 353.82100 | |
| Density | 1.378g/cm3 | Boiling Point | 555.3ºC at 760 mmHg | |
| Molecular Formula | C16H16ClNO4S | Melting Point | 132.5-137.4 °C(lit.) | |
| MSDS | USA | Flash Point | 289.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cyclooxygenase-2 inhibition and thromboxane A(2) receptor antagonism attenuate hypoxic pulmonary vasoconstriction in a porcine model.
Acta Physiol. (Oxf.) 205(4) , 507-19, (2012) Hypoxic pulmonary vasoconstriction (HPV) causes pulmonary hypertension that may lead to right heart failure. We hypothesized that the COX-2 inhibitor nimesulide and the thromboxane A(2) receptor antagonist daltroban would attenuate HPV.Haemodynamic measuremen... |
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Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Thromb. Haemost. 87(1) , 114-21, (2002) Arachidonic acid (AA) is a potent inducer of platelet aggregation in vitro; this activity is due to its conversion to biologically active metabolites, prostaglandin (PG) endoperoxides and thromboxane A2 (TxA2). PG endoperoxides and TxA, are thought to act on ... |
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Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes.
Hepatology 30 , 454-461, (1999) In the perfused rat liver the anaphylatoxin C5a enhanced glucose output, reduced flow, and elevated prostanoid overflow. Because hepatocytes (HCs) do not express C5a receptors, the metabolic C5a actions must be indirect, mediated by e.g. prostanoids from Kupf... |
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Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion.
Am. J. Physiol. Heart Circ. Physiol. 301(5) , H2140-6, (2011) Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstiti... |
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Differences in the involvement of prostanoids from Kupffer cells in the mediation of anaphylatoxin C5a-, zymosan-, and lipopolysaccharide-dependent hepatic glucose output and flow reduction.
Lab. Invest. 83(12) , 1733-41, (2003) Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells... |
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Growth inhibitory effects of thromboxane antagonists on breast cancer cell lines: a preliminary study.
Adv. Exp. Med. Biol. 400A , 455-60, (1997)
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Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs.
J. Pharmacol. Exp. Ther. 290(3) , 1285-91, (1999) The role of cysteinyl leukotrienes (cys-LTs) and thromboxane A(2) (TXA(2)) in guinea pig models of aspects of bronchial asthma was investigated. In a novel antigen (BSA)-induced asthmatic model using passively sensitized guinea pigs, pretreatment with varying... |
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Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist.
Eur. J. Pharmacol. 357(1) , 53-60, (1998) We investigated the pharmacological characteristics of Z-335 ((+/-)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]ace tate monohydrate), a new indan derivative. Z-335 inhibited the specific binding of [3H]SQ-29548 to human platelets and guinea pig p... |
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Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022.
Eur. J. Pharmacol. 328(2-3) , 183-9, (1997) The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically... |
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Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate.
Biochem. Pharmacol. 66(4) , 643-52, (2003) Prostanoids, i.e. prostaglandins and thromboxane, regulate liver-specific functions both in homeostasis and during defense reactions. For example, prostanoids are released from Kupffer cells, the resident liver macrophages, in response to the inflammatory med... |