79094-20-5

79094-20-5 structure

Name: Daltroban
Chemical Name: Daltroban
CAS Number: 79094-20-5
Molecular Formula: C₁₆H₁₆ClNO₄S
Molecular Weight: 353.82100
Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
Create Date: 2018-08-03 13:04:20
Modify Date: 2024-01-10 11:33:45
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2].

Name	Daltroban
Synonyms	4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid [4-[2-(4-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid 2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid 4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID DatelliptiumChloride 2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid 4-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenylacetic acid 4-((((4-chlorophenyl)sulfonyl)amino)ethyl)benzene acetic acid MFCD00868295

Description	Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	TXA2
In Vivo	Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats[2]. In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis[3]. Animal Model: Adult male cats (2.8 to 4.6 kg; anesthetized cat model)[2] Dosage: 1 mg/kg Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour Result: Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.
References	[1]. Miki I, et al. Differences in activities of thromboxane A2 receptor antagonists in smooth muscle cells. Eur J Pharmacol. 1992 Oct 1;227(2):199-204. [2]. Thiemermann C, et al. The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. Eur J Pharmacol. 1988 Oct 11;155(1-2):57-67. [3]. Bhat AM, et al. Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats. Am Heart J. 1989 Apr;117(4):799-803.

Density	1.378g/cm3
Boiling Point	555.3ºC at 760 mmHg
Melting Point	132.5-137.4 °C(lit.)
Molecular Formula	C₁₆H₁₆ClNO₄S
Molecular Weight	353.82100
Flash Point	289.6ºC
Exact Mass	353.04900
PSA	91.85000
LogP	3.95980
Appearance	white
Vapour Pressure	3.63E-13mmHg at 25°C
Index of Refraction	1.609
Water Solubility	DMSO: 22 mg/mL, soluble

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3

98-60-2

79094-20-5

Literature: European Journal of Medicinal Chemistry, , vol. 26, # 8 p. 821 - 827

Precursor 1
98-60-2
DownStream 0