79094-20-5
79094-20-5 structure
- Name: Daltroban
- Chemical Name: Daltroban
- CAS Number: 79094-20-5
- Molecular Formula: C16H16ClNO4S
- Molecular Weight: 353.82100
- Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
- Create Date: 2018-08-03 13:04:20
- Modify Date: 2025-08-25 18:50:29
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Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2].
| Name | Daltroban |
|---|---|
| Synonyms |
4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid
[4-[2-(4-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid 2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid 4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID DatelliptiumChloride 2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid 4-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenylacetic acid 4-((((4-chlorophenyl)sulfonyl)amino)ethyl)benzene acetic acid MFCD00868295 |
| Description | Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2]. |
|---|---|
| Related Catalog | |
| Target |
TXA2 |
| In Vivo | Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats[2]. In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis[3]. Animal Model: Adult male cats (2.8 to 4.6 kg; anesthetized cat model)[2] Dosage: 1 mg/kg Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour Result: Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand. |
| References |
| Density | 1.378g/cm3 |
|---|---|
| Boiling Point | 555.3ºC at 760 mmHg |
| Melting Point | 132.5-137.4 °C(lit.) |
| Molecular Formula | C16H16ClNO4S |
| Molecular Weight | 353.82100 |
| Flash Point | 289.6ºC |
| Exact Mass | 353.04900 |
| PSA | 91.85000 |
| LogP | 3.95980 |
| Appearance | white |
| Vapour Pressure | 3.63E-13mmHg at 25°C |
| Index of Refraction | 1.609 |
| Water Solubility | DMSO: 22 mg/mL, soluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
~%
79094-20-5 |
| Literature: European Journal of Medicinal Chemistry, , vol. 26, # 8 p. 821 - 827 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |