Ochratoxin B
Ochratoxin B structure
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Common Name | Ochratoxin B | ||
|---|---|---|---|---|
| CAS Number | 4825-86-9 | Molecular Weight | 369.368 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 632.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H19NO6 | Melting Point | 221ºC | |
| MSDS | USA | Flash Point | 336.2±31.5 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on Penicillium.
Toxins (Basel.) 4(12) , 1535-51, (2012) It has previously been shown that the biosynthesis of the mycotoxins ochratoxin A and B and of citrinin by Penicillium is regulated by light. However, not only the biosynthesis of these mycotoxins, but also the molecules themselves are strongly affected by li... |
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Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high-performance liquid chromatography.
J. Chromatogr. A. 864(1) , 89-101, (1999) A new and accurate method to quantify ochratoxin A (OA) in table wine has been developed. The method uses commercial immunoaffinity columns for clean-up and high-performance liquid chromatography (HPLC) with fluorescence detection for quantification of the to... |
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Determination of ochratoxin A in grains by immuno-ultrafiltration and HPLC-fluorescence detection after postcolumn derivatisation in an electrochemical cell.
Anal. Bioanal. Chem 400(8) , 2615-22, (2011) The paper presents a new sample clean-up method based on immuno-ultrafiltration for the analysis of ochratoxin A in cereals. In contrast to immunoaffinity chromatography, in immuno-ultrafiltration, the antibodies are used in non-immobilised form. Ochratoxin A... |
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Suppression of ochratoxin biosynthesis by naturally occurring alkaloids.
Food Addit. Contam. 24(4) , 391-7, (2007) The effects of four alkaloids on the biosynthesis of ochratoxin A (OTA), ochratoxin B (OTB) and citrinin were examined on four OTA-producing aspergilli: Aspergillus auricomus, A. sclerotiorum and two isolates of A. alliaceus. Piperine and piperlongumine, natu... |
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Production and characterization of monoclonal antibodies against ochratoxin B.
Food Chem. Toxicol. 45(5) , 827-33, (2007) Monoclonal antibodies against ochratoxin B (OTB) were generated by immunizing Balb/c mice with OTB conjugated to keyhole limpet hemocyanin (KLH) via carbodiimide reactions with CHMC and EDAC. A stable hybridoma cell line 2F1.E10 was produced by fusion of muri... |
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Species- and sex-specific renal cytotoxicity of ochratoxin A and B in vitro.
Exp. Toxicol. Pathol. 53(2-3) , 215-25, (2001) Four different cell models were chosen for comparison of OTA and OTB toxicity: primary porcine (PKC), rat (RPTC) and human renal proximal epithelial cells (HKC) from both sexes and a porcine renal cell line: LLC-PK1. Culture conditions were tested and optimiz... |
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Ochratoxin A and some of its derivatives modulate radical formation of porcine blood monocytes and granulocytes.
Toxicology 199(2-3) , 251-9, (2004) Modulating effects of ochratoxin A (OTA) and some of its derivatives on viability and oxidative burst activity of porcine monocytes and granulocytes have been studied. The formation of free oxygen radicals by monocytes was suppressed by OTA and ochratoxin C (... |
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Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs.
J. Nutr. 134(9) , 2355-8, (2004) The mycotoxin ochratoxin A (OA) is a cause of endemic nephropathy in farm animals and humans. Reabsorption of OA along the nephron results from nonionic diffusion and by carrier-mediated mechanisms, indicating that urine alkalinization may help to accelerate ... |
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Determination of ochratoxin A at parts-per-trillion levels in cereal products by immunoaffinity column cleanup and high-performance liquid chromatography/mass spectrometry.
J. AOAC Int. 90(3) , 773-7, (2007) Ochratoxin A (OTA) is a toxic and potentially carcinogenic fungal toxin found in a variety of food commodities. A new sensitive method has been developed to quantify OTA in cereal products by reversed-phase liquid chromatography (LC) with mass spectrometric (... |
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Effects of repeated ochratoxin exposure on renal cells in vitro.
Toxicol. In Vitro 21(1) , 72-80, (2007) In the present study an in vitro model of subchronic repeated exposure to OTA and OTB was employed to generate ochratoxin-derived subpopulations of human and porcine proximal tubular cells (HKC, IHKE, PKC, LLC-PK1). These cell subpopulations were subsequently... |