Harmane
Harmane structure
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Common Name | Harmane | ||
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| CAS Number | 486-84-0 | Molecular Weight | 182.221 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 386.9±22.0 °C at 760 mmHg | |
| Molecular Formula | C12H10N2 | Melting Point | 235-238 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 176.2±13.6 °C | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
Bioorg. Med. Chem. 16 , 6689, (2008) Twenty-three heterocyclic compounds were evaluated for their potential as trypanothione reductase inhibitors. As a result, the harmaline, 10-thiaisoalloxazine, and aspidospermine frameworks were identified as the basis of inhibitors of Trypanosoma cruzi trypa... |
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Nonaqueous capillary electrophoresis as separation technique to support metabolism studies by means of electrochemistry and mass spectrometry.
Electrophoresis 35(16) , 2386-91, (2014) The first combination of electrochemistry (EC), NACE, and ESI-MS to mimic the metabolic fate of drugs is described. While the combination of EC, HPLC, and ESI-MS has been used for this purpose before, NACE is able to deliver valuable additional information ab... |
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Identification and characterization of mefloquine efficacy against JC virus in vitro.
Antimicrob. Agents Chemother. 53 , 1840-9, (2009) Progressive multifocal leukoencephalopathy (PML) is a rare but frequently fatal disease caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of some immunocompromised individuals. Currently, no effective antiviral treatment ... |
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A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.
J. Med. Chem. 53 , 3106-16, (2010) 3S-Tetrahydro-beta-carboline-3-carboxylic acid (TCCA) effectively inhibits ADP-induced platelet activation. This paper used TCCA as a lead, modified its 2-position with amino acids, and provided 20 novel 3S-2-aminoacyl-1,2,3,4-tetrahydro-beta-carboline-3-carb... |
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A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.
Eur. J. Med. Chem. 46 , 5598-608, (2011) High anti-thrombotic activity of aminoacid modified tetrahydro-β-carbolines was generally correlated with a small proximity of the side chain of the aminoacid residue to the carboline-cycle. This paper explored that the aromatization of the tetrahydro-β-carbo... |
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Suggesting a possible role of CA1 histaminergic system in harmane-induced amnesia.
Neurosci. Lett. 556 , 5-9, (2013) A number of tremorogenic β-carboline alkaloids such as harmane are naturally present in the human food chain. They are derived from medicinal plants such as Peganum harmala that have been used as folk medicine in anticancer therapy. In the present study, effe... |
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Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test.
Eur. J. Pharmacol. 634(1-3) , 77-83, (2010) Ingestion of harmane and other alkaloids derived from plant Peganum harmala has been shown to elicit profound behavioural and toxic effects in humans, including hallucinations, excitation, feelings of elation, and euphoria. These alkaloids in the high doses c... |
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Detection of bioactive exometabolites produced by the filamentous marine cyanobacterium Geitlerinema sp.
Mar. Biotechnol. 14(4) , 436-45, (2012) Marine cyanobacteria are noted for their ability to excrete metabolites with biotic properties. This paper focuses on such exometabolites obtained from the culture of the marine filamentous cyanobacterium Geitlerinema sp. strain, their purification and subseq... |