486-84-0

486-84-0 structure

Name: Harmane
Chemical Name: harman
CAS Number: 486-84-0
Molecular Formula: C₁₂H₁₀N₂
Molecular Weight: 182.221
Catalog: Biochemical Biochemical reagent Biological dye
Create Date: 2018-08-15 14:47:02
Modify Date: 2024-01-08 10:42:42
Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4].

Name	harman
Synonyms	1-Methyl-9H-β-carboline 2-Methyl-b-carboline Harmane Aribine MFCD00004957 Harman 1-Methyl-β-carboline 1-methylbetacarboline Aribin 1-Methyl-9H-pyrid[3,4-b]indole EINECS 207-642-2 9H-Pyrido[3,4-b]indole, 1-methyl- Passiflorin Loturine 1-methyl-9H-pyrido[3,4-b]indole 1-Me-carboline Locuturine Locuturin Phorbol 12,13-dibutyrate

Description	Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50)
References	[1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,249,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21
Safety Phrases	S22-S24/25
RIDADR	1544
WGK Germany	3
RTECS	UV0280000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%