FG 7142
FG 7142 structure
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Common Name | FG 7142 | ||
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| CAS Number | 78538-74-6 | Molecular Weight | 225.24600 | |
| Density | 1.328g/cm3 | Boiling Point | 576.3ºC at 760 mmHg | |
| Molecular Formula | C13H11N3O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 302.3ºC | |
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Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs.
Behav. Brain Res. 235(1) , 21-9, (2012) Vestibular dysfunction in humans is associated with anxiety and cognitive disorders. However, various animal studies of the effects of vestibular loss have yielded conflicting results, from reduced anxiety to increased anxiety, depending on the particular mod... |
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Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model.
Psychoneuroendocrinology 65 , 127-37, (2016) Distressing symptoms such as hot flashes and sleep disturbances affect over 70% of women approaching menopause for an average of 4-7 years, and recent large cohort studies have shown that anxiety and stress are strongly associated with more severe and persist... |
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The influence of NMDA and GABA(A) receptors and glutamic acid decarboxylase (GAD) activity on attention.
Psychopharmacology 225(1) , 31-9, (2013) Attention dysfunction is the hallmark of cognitive deficits associated with major psychiatric illnesses including schizophrenia. Cognitive deficits of schizophrenia have been attributed to reduced function of the N-methyl-D-aspartate (NMDA) receptor or reduce... |
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The effects of FG 7142 on sensory-specific satiety in rats.
Behav. Brain Res. 209(1) , 131-6, (2010) Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested with the sa... |
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Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat
Behav. Brain Res. 233(1) , 191-200, (2012) Highlights ► Exercise does not reliably alter anxiety-like and defensive behaviors at baseline. ► Anxiolytic potential of exercise emerges after mild-to-moderate intensity stress. ► Locus coeruleus galanin is elevated by exercise and correlates with wheel run... |
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Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice.
Psychopharmacology 213(2-3) , 453-63, (2011) 5-HT(1A) receptor knockout (1AKO) mice have a robust anxiety phenotype. Tissue-specific "rescue" strategies and electrophysiology have implicated a critical role for postsynaptic 5-HT(1A) receptors, particularly in the CA1 region of the hippocampus.In this st... |
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Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia.
Behav. Brain Res. 252 , 405-14, (2013) Social withdrawal is one of several negative symptoms of schizophrenia, all of which are poorly treated by current therapies. One challenge in developing agents with efficacy against negative symptoms is the lack of suitable preclinical models. The social app... |
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Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats.
Physiol. Behav. 107(5) , 719-25, (2012) Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Theref... |
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Renewal and spontaneous recovery, but not latent inhibition, are mediated by gamma-aminobutyric acid in appetitive conditioning.
J. Exp. Psychol. Anim. Behav. Process. 35(2) , 224-37, (2009) Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, ... |
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Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems.
Brain Res. 1443 , 1-17, (2012) Our previous studies have shown that post-weaning social isolation of male rats leads to sensitization of serotonergic systems and increases in anxiety-like behavior in adulthood. Although studies in humans suggest that females have an increased sensitivity t... |