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78538-74-6

78538-74-6 structure
78538-74-6 structure
  • Name: FG 7142
  • Chemical Name: N-Methyl-b-carboline-3-carboxamide
  • CAS Number: 78538-74-6
  • Molecular Formula: C13H11N3O
  • Molecular Weight: 225.24600
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2019-02-22 11:41:34
  • Modify Date: 2025-08-24 20:47:59
  • FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1].
Name N-Methyl-b-carboline-3-carboxamide
Synonyms B-carboline-3-carboxylic acid N-*methylamide
FG 7142
Description FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1].
Related Catalog
In Vitro FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively[1]. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM,α3=1.021μM , α5=1.439 μM)[1].
In Vivo FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats[1]. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas[1].
References

[1]. Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32(5):1069-81. Epub 2006 Nov 1.
Density 1.328g/cm3
Boiling Point 576.3ºC at 760 mmHg
Molecular Formula C13H11N3O
Molecular Weight 225.24600
Flash Point 302.3ºC
Exact Mass 225.09000
PSA 57.78000
LogP 2.46660
Index of Refraction 1.735
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU9780100
CHEMICAL NAME :
9H-Pyrido(3,4-b)indole-3-carboxamide, N-methyl-
CAS REGISTRY NUMBER :
78538-74-6
LAST UPDATED :
199212
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H11-N3-O
MOLECULAR WEIGHT :
225.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 12-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 22,53,1991
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UU9780100
HS Code 2933990090
69954-48-9 structure

69954-48-9

74-89-5 structure

74-89-5

~43%

78538-74-6 structure

78538-74-6

Literature: A/S Ferrosan; Scherling AG Patent: US4371536 A1, 1983 ; US 4371536 A
73-22-3 structure

73-22-3

~%

78538-74-6 structure

78538-74-6

Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142
6052-68-2 structure

6052-68-2

~%

78538-74-6 structure

78538-74-6

Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142
16253-64-8 structure

16253-64-8

~%

78538-74-6 structure

78538-74-6

Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142
593-51-1 structure

593-51-1

40678-46-4 structure

40678-46-4

~%

78538-74-6 structure

78538-74-6

Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336
593-51-1 structure

593-51-1

42438-90-4 structure

42438-90-4

~%

78538-74-6 structure

78538-74-6

Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336
50-99-7 structure

50-99-7

593-51-1 structure

593-51-1

73-22-3 structure

73-22-3

~%

78538-74-6 structure

78538-74-6

Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336
74214-62-3 structure

74214-62-3

74-89-5 structure

74-89-5

~%

78538-74-6 structure

78538-74-6

Literature: Lin, Guowu; Wang, Yue; Zhou, Qingfa; Tang, Weifang; Wang, Jian; Lu, Tao Molecules, 2010 , vol. 15, # 8 p. 5680 - 5691
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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