FG 7142
FG 7142 structure
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Common Name | FG 7142 | ||
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| CAS Number | 78538-74-6 | Molecular Weight | 225.24600 | |
| Density | 1.328g/cm3 | Boiling Point | 576.3ºC at 760 mmHg | |
| Molecular Formula | C13H11N3O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 302.3ºC | |
Use of FG 7142FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1]. |
| Name | N-Methyl-b-carboline-3-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1]. |
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| Related Catalog | |
| In Vitro | FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively[1]. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM,α3=1.021μM , α5=1.439 μM)[1]. |
| In Vivo | FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats[1]. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas[1]. |
| References |
| Density | 1.328g/cm3 |
|---|---|
| Boiling Point | 576.3ºC at 760 mmHg |
| Molecular Formula | C13H11N3O |
| Molecular Weight | 225.24600 |
| Flash Point | 302.3ºC |
| Exact Mass | 225.09000 |
| PSA | 57.78000 |
| LogP | 2.46660 |
| Index of Refraction | 1.735 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UU9780100 |
| HS Code | 2933990090 |
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~43%
FG 7142 CAS#:78538-74-6 |
| Literature: A/S Ferrosan; Scherling AG Patent: US4371536 A1, 1983 ; US 4371536 A |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Couts, Ronald T.; Micetich, Ronald G.; Baker, Glen B; Benderly, Abraham; Dewhurst, Tim; et al. Heterocycles, 1984 , vol. 22, # 1 p. 131 - 142 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336 |
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~%
FG 7142 CAS#:78538-74-6 |
| Literature: Lin, Guowu; Wang, Yue; Zhou, Qingfa; Tang, Weifang; Wang, Jian; Lu, Tao Molecules, 2010 , vol. 15, # 8 p. 5680 - 5691 |
![(1S,3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid structure](https://image.chemsrc.com/caspic/179/40678-46-4.png)
| Precursor 10 | |
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| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| B-carboline-3-carboxylic acid N-*methylamide |
| FG 7142 |