FG-2216

Modify Date: 2025-08-22 18:15:26

FG-2216 structure	Common Name	FG-2216
	CAS Number	223387-75-5	Molecular Weight	280.66400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₉ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FG-2216

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.IC50 value: 3.9 uM [1]Target: PDH inhibitorFG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].

Name	[[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid
Synonym	More Synonyms

Description	FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.IC50 value: 3.9 uM [1]Target: PDH inhibitorFG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Others
References	[1]. Hong YR, et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7. [2]. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

Research Areas >> Others

References

[1]. Hong YR, et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.

[2]. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.

Molecular Formula	C₁₂H₉ClN₂O₄
Molecular Weight	280.66400
Exact Mass	280.02500
PSA	99.52000
LogP	1.79910
InChIKey	OUQVKRKGTAUJQA-UHFFFAOYSA-N
SMILES	O=C(O)CNC(=O)c1nc(Cl)c2ccccc2c1O
Storage condition	-20℃

[(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]acetic acid

[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid

[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid

(N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid

Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-

N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine

N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine

FG-2216

[(1chloro-4-hydroxy-isoquinoline-3-carbonyl)amino]-acetic acid

FG2216

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FG-2216
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: FG-2216
Price: ￥1166.0/5mg ￥736.0/1mg ￥1846.0/10mg ￥11686.0/100mg
Purity: 99.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: FG2216
Price: $450.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: FG2216
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $66/10mM*1mLinDMSO

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FG-2216

Use of FG-2216

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FG-2216 Biological Activity

Chemical & Physical Properties

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