Behavioural Brain Research 2012-07-15

Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat

Natale R. Sciolino, Rodney K. Dishman, Philip V. Holmes, Natale R. Sciolino, Rodney K. Dishman, Philip V. Holmes, Natale R. Sciolino, Rodney K. Dishman, Philip V. Holmes

Index: Behav. Brain Res. 233(1) , 191-200, (2012)

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Abstract

Highlights ► Exercise does not reliably alter anxiety-like and defensive behaviors at baseline. ► Anxiolytic potential of exercise emerges after mild-to-moderate intensity stress. ► Locus coeruleus galanin is elevated by exercise and correlates with wheel running. ► A role for galanin in the beneficial consequences of wheel running is supported.