N-Hydroxybenzenecarboximidamide
N-Hydroxybenzenecarboximidamide structure
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Common Name | N-Hydroxybenzenecarboximidamide | ||
|---|---|---|---|---|
| CAS Number | 613-92-3 | Molecular Weight | 136.151 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 307.4±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H8N2O | Melting Point | 77°C | |
| MSDS | Chinese USA | Flash Point | 139.7±23.2 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A novel and specific fluorescence reaction for uracil.
Anal. Chim. Acta 674(2) , 234-8, (2010) Facile and specific methods to quantify a nucleobase in biological samples are of great importance for diagnosing disorders in nucleic acid metabolism. In the present study, a novel fluorogenic reaction specific for uracil has been developed. The reaction was... |
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Characteristics of the microsomal N-hydroxylation of benzamidine to benzamidoxime.
Xenobiotica 17(6) , 659-67, (1987) 1. A simple and fast h.p.l.c. analysis of benzamidoxime formed by microsomal N-hydroxylation of benzamidine is presented which is well suited for the determination of the N-oxygenation activity of microsomal enzymes. 2. Optimal reaction conditions were determ... |
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Biotransformation of benzamidine and benzamidoxime in vivo.
Arch. Pharm. (Weinheim) 326(10) , 807-12, (1993) After administration of benzamidine (1) or benzamidoxime (2), respectively, to rats and rabbits, plasma from rats and rabbits as well as urine from rats were examined for the presence of benzamidoxime (2) or benzamidine (1). Some of the samples were worked-up... |
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Genotoxic activities of benzamidine and its N-hydroxylated metabolite benzamidoxime in Salmonella typhimurium and mammalian cells.
J. Cancer Res. Clin. Oncol. 114(4) , 363-8, (1988) The genotoxic potentials of benzamidine and benzamidoxime were determined to study the toxicological relevance of the metabolic N-oxygenation (N-hydroxylation) of benzamidines to benzamidoximes. Benzamidoxime induced DNA single-strand breaks (in rat hepatocyt... |
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[Biotransformation of benzamidine and benzamidoxime by microsomal enzymes of the rabbit].
Arch. Pharm. (Weinheim) 322(7) , 431-5, (1989) At pH 7.4 neither benzamidine (1) is ring-hydroxylated nor benzamidoxime (2) is N-hydroxylated, reduced or ring-hydroxylated by aerobic incubations with microsomal fractions (12000 g supernatant, microsomes) of rabbit liver homogenates and NADPH. Products of ... |
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Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases.
Xenobiotica 35(1) , 17-25, (2005) N-Hydroxyamidines (amidoximes) can act as pro-drugs of amidines (e.g. ximelagatran, a novel direct thrombin inhibitor). This known pro-drug principle is based on the N-reduction of an oral bioavailable amidoxime to its active form. Previous study of the metab... |
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Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs.
Xenobiotica 38(9) , 1177-90, (2008) 1. This study investigates the enzymatic reduction of N-hydroxylated amidines by porcine adipose tissue and the possible involvement of stearoyl-CoA desaturase (SCD). 2. The reduction of the model substrate benzamidoxime was studied with porcine adipose tissu... |
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Sensitive and Selective Determination of Orotic Acid in Biological Specimens Using a Novel Fluorogenic Reaction.
J. Fluoresc. 25 , 1005-11, (2015) Orotic acid is an intermediate in the synthesis pathway of uridine-5'-monophosphate, and increases in body fluids of patients suffering from hereditary disorders such as orotic aciduria and hyperammonemia. In this study, we developed a spectrofluorometric met... |
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Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime.
Drug Metab. Dispos. 33(4) , 570-578, (2005) The enzymic basis for intracellular reduction of N-hydroxylated amidines to their corresponding amidines, and hydroxylamines to their corresponding amines, is unknown. The hydroxylated amidines can be used as prodrug moieties, and an understanding of the enzy... |
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Insight into technetium amidoxime complex: oxo technetium(V) complex of N-substituted benzamidoxime as new basic structure for molecular imaging.
Inorg. Chem. 50(3) , 992-8, (2011) In search of benzamidoxime (BHam) derivatives that provide a single (99m)Tc-labeled compound of high in vivo stability, we synthesized three N-alkyl compounds of benzamidoxime (BHam) ligand. They provided a single (99m)Tc-labeled compound by ligand exchange r... |