5-Fluoro-2-hydroxybenzoic acid
5-Fluoro-2-hydroxybenzoic acid structure
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Common Name | 5-Fluoro-2-hydroxybenzoic acid | ||
|---|---|---|---|---|
| CAS Number | 345-16-4 | Molecular Weight | 156.111 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 307.4±27.0 °C at 760 mmHg | |
| Molecular Formula | C7H5FO3 | Melting Point | 177-179 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 139.7±23.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Quantification of free and total salicylic acid in plants by solid-phase extraction and isocratic high-performance anion-exchange chromatography.
Anal. Bioanal. Chem 382(7) , 1620-7, (2005) Salicylic acid (SA) is an important signaling compound in plants and is involved in various defense responses. Here we report a new method for quantification of free and total soluble SA in Arabidopsis thaliana with 5-fluorosalicylic acid (5-FSA) as internal ... |
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Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates.
Anal. Chem. 64(4) , 342-6, (1992) We report an ultrasensitive, enzymatically amplified, time-resolved fluorescence immunoassay with a terbium chelate as the detectable moiety. In this immunoassay, the primary label is the enzyme alkaline phosphatase (ALP). ALP cleaves phosphate out of a fluor... |
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Cα-C bond cleavage of the peptide backbone in MALDI in-source decay using salicylic acid derivative matrices.
J. Am. Soc. Mass Spectrom. 22(7) , 1224-33, (2011) The use of 5-formylsalicylic acid (5-FSA) and 5-nitrosalicylic acid (5-NSA) as novel matrices for in-source decay (ISD) of peptides in matrix-assisted laser desorption/ionization (MALDI) is described. The use of 5-FSA and 5-NSA generated a- and x-series ions ... |
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Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Bioorg. Med. Chem. 15 , 6535-48, (2007) A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those de... |
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Effect of fluorine position on the coordinating ability of fluorosalicylic acids--an experimental study complemented with computations.
J. Inorg. Biochem. 105(1) , 75-83, (2011) The complexation of 3-, 4-, and 6-fluorosalicylic acids (HL) with copper(II) was investigated in aqueous solution by pH-potentiometry combined with UV-visible spectrophotometry, and in 50 v/v % water-methanol mixture by the two-dimensional ESR simulation meth... |
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Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV-vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra.
J. Inorg. Biochem. 102(1) , 101-9, (2008) The copper(II)-5-fluorosalicylic acid system was investigated in water and 50 v/v% water-methanol mixture by pH potentiometry combined with UV-vis spectrophotometry, and by the two-dimensional ESR simulation method, respectively. The data revealed that the st... |