R(+)-SKF-38393A
R(+)-SKF-38393A structure
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Common Name | R(+)-SKF-38393A | ||
|---|---|---|---|---|
| CAS Number | 81702-42-3 | Molecular Weight | 291.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18ClNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors, which are the main target of antipsychotics, modulate the ... |
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Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
Bioorg. Med. Chem. 19 , 5420-31, (2011) To assess the effect of conformational mobility on receptor activity, the β-phenyl substituent of dopamine D(1) agonist ligands of the phenylbenzazepine class, (±)-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepine-11,12-diol (8), and its oxygen and su... |
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Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.
Psychopharmacology 107 , 217, (1992) The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N = 4) were trained with food reinforcement to press one of two levers after administrat... |
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Stimulation of dopamine D-1 receptors by SKF 38393 induces EEG desynchronization and behavioral arousal.
Life Sci. 37 , 2327, (1985) The dopamine D-1 receptor agonist SKF 38393 dose-dependently (2.5-10 mg/kg) induced desynchronization of the electroencephalographic (EEG) activity and behavioral arousal in both rabbits and rats. Unlike apomorphine, SKF 38393 elicited no signs of stereotyped... |
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Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.
J. Med. Chem. 25 , 697, (1982) Resolution of the unique dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (1) was achieved by a stereospecific multistep conversion of the readily separated enantiomers of its O,O,N-trimethylated precursor 2. The absolute s... |