81702-42-3

81702-42-3 structure

Name: R(+)-SKF-38393A
Chemical Name: (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride
CAS Number: 81702-42-3
Molecular Formula: C₁₆H₁₈ClNO₂
Molecular Weight: 291.77
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2017-10-02 23:42:36
Modify Date: 2025-08-25 19:01:29
(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].

Name	(5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride
Synonyms	MFCD00055189

Description	(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Risk Phrases	36/37/38
Safety Phrases	26-36-22
RIDADR	NONH for all modes of transport