5-(N-Methyl-N-isobutyl)-Amiloride
5-(N-Methyl-N-isobutyl)-Amiloride structure
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Common Name | 5-(N-Methyl-N-isobutyl)-Amiloride | ||
|---|---|---|---|---|
| CAS Number | 96861-65-3 | Molecular Weight | 299.76000 | |
| Density | 1.49g/cm3 | Boiling Point | 543.9ºC at 760mmHg | |
| Molecular Formula | C11H18ClN7O | Melting Point | 200-201 °C | |
| MSDS | Chinese USA | Flash Point | 282.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer.
Int. J. Oncol. 46(4) , 1788-800, (2015) We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chromatography, LC-MS/MS analysis, co-immunoprecipitation, and RN... |
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Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.
Cancer Biol. Ther. 16(3) , 438-49, (2015) Tumors often contain hypoxic regions resistant to chemo- and radiotherapy. TH-302 (T) is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoramide mustard under hypoxic conditions. This study evaluated ... |
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Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.
Nat. Commun. 6 , 6426, (2015) Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is significantly increased when mice are housed at a thermoneutr... |
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Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I.
Biosci. Biotechnol. Biochem. 79 , 1061-6, (2015) Amilorides, well-known inhibitors of Na(+)/H(+) antiporters, have also shown to inhibit bacterial and mitochondrial NADH-quinone oxidoreductase (complex I). Since the membrane subunits ND2, ND4, and ND5 of bovine mitochondrial complex I are homologous to Na(+... |
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Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency.
Hum. Reprod. 30(3) , 608-15, (2015) Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insufficiency (POI)?Our vitrification approach followed by IVA tr... |
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The Oxidation Status of Mic19 Regulates MICOS Assembly.
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Porphyrin-phospholipid liposomes with tunable leakiness.
J. Control. Release 220 , 484-94, (2015) Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the ... |
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Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.
PLoS ONE 10 , e0132572, (2015) The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g. cell number and media volume. Dependence on physical aspects is often overl... |
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Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes.
World J. Gastroenterol. 21(13) , 3876-87, (2015) To evaluate/isolate cancer stem cells (CSCs) from tissue or cell lines according to various definitions and cell surface markers.Lectin microarray analysis was conducted on CSC-like fractions of the human pancreatic cancer cell line Panc1 by establishing anti... |
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Silencing of miR-101 Prevents Cartilage Degradation by Regulating Extracellular Matrix-related Genes in a Rat Model of Osteoarthritis.
Mol. Ther. 23 , 1331-40, (2015) Osteoarthritis (OA) is a common, degenerative joint disease characterized by articular cartilage degradation. Currently, clinical trials based on microRNA therapy have been performed to treat various diseases. However, no treatment has been found for arthriti... |