5-(N-Methyl-N-isobutyl)-Amiloride

Modify Date: 2024-01-16 09:03:49

5-(N-Methyl-N-isobutyl)-Amiloride Structure
5-(N-Methyl-N-isobutyl)-Amiloride structure
Common Name 5-(N-Methyl-N-isobutyl)-Amiloride
CAS Number 96861-65-3 Molecular Weight 299.76000
Density 1.49g/cm3 Boiling Point 543.9ºC at 760mmHg
Molecular Formula C11H18ClN7O Melting Point 200-201 °C
MSDS Chinese USA Flash Point 282.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 3-amino-6-chloro-N-(diaminomethylidene)-5-[methyl(2-methylpropyl)amino]pyrazine-2-carboxamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.49g/cm3
Boiling Point 543.9ºC at 760mmHg
Melting Point 200-201 °C
Molecular Formula C11H18ClN7O
Molecular Weight 299.76000
Flash Point 282.8ºC
Exact Mass 299.12600
PSA 134.01000
LogP 2.34230
Index of Refraction 1.664

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR UN 2811
Packaging Group III
Hazard Class 6.1(b)

 Articles113

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Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.

Cancer Biol. Ther. 16(3) , 438-49, (2015)

Tumors often contain hypoxic regions resistant to chemo- and radiotherapy. TH-302 (T) is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoram...

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

Nat. Commun. 6 , 6426, (2015)

Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is si...

 Synonyms

5-(N-Methyl-N-isobutyl)amiloride
Methylisobutylamiloride
MFCD00078567
Lopac-A-5585
5-Nmnia
3-amino-6-chloro-n-(diaminomethylene)-5-[isobutyl(methyl)amino]pyrazine-2-carboxamide
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