Methylthiouracil
Methylthiouracil structure
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Common Name | Methylthiouracil | ||
|---|---|---|---|---|
| CAS Number | 56-04-2 | Molecular Weight | 142.179 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 342.3ºC at 760 mmHg | |
| Molecular Formula | C5H6N2OS | Melting Point | ~330 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 160.8ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Hydration energies of protonated and sodiated thiouracils.
J. Am. Soc. Mass Spectrom. 25(12) , 2134-42, (2014) Hydration reactions of protonated and sodiated thiouracils (2-thiouracil, 6-methyl-2-thiouracil, and 4-thiouracil) generated by electrospray ionization have been studied in a gas phase at 10 mbar using a pulsed ion-beam high-pressure mass spectrometer. The th... |
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Simultaneous determination of thyreostatic residues in animal tissues by matrix solid-phase dispersion and gas chromatography-mass spectrometry.
J. Chromatogr. A. 1074 , 1-7, (2005) A method for determination of thyreostatic residues in animal tissues by matrix solid-phase dispersion (MSPD) and gas chromatography-mass spectrometry in selected ion detection mode was developed. Thyreostatic compounds in different matrices were extracted an... |
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Combinations of growth promoters in veal calves: consequences for screening and confirmation methods.
Zentralbl. Veterinarmed. A 45(6-7) , 425-40, (1998) This study investigates the influence of low dosages of beta-agonists combined with other growth promoters on screening and confirmation methods in male veal calves. Five groups of four calves were treated for 6 weeks with combinations of low dosages of beta-... |
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Histomorphometry and quantification of nucleolar organizer regions in bovine thyroid containing methylthiouracil residues.
Vet. Pathol. 36(6) , 574-82, (1999) In order to study the morphology and morphometry and to characterize and quantify the nucleolar organizer regions (NORs) of bovine thyroids containing methylthiouracil (MTU) residues, five animals were orally treated with a suspension of MTU (5 g/animal/day) ... |
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Induction of manganese superoxide dismutase by thyroid stimulating hormone in rat thyroid cells.
FEBS Lett. 416(1) , 69-71, (1997) Alterations in the superoxide dismutase (SOD) content of thyroid tissues occurring in association with thyroid dysfunction have been reported. In this study, the Mn-SOD content was found to increase in thyroid tissues of rats administered thyroid stimulating ... |
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Determination of propylthiouracil and methylthiouracil in human serum using high-performance liquid chromatography with chemiluminescence detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 854(1-2) , 239-44, (2007) Based on the sensitizing effect of formaldehyde on the chemiluminescence (CL) reaction of propylthiouracil (PTU) and methylthiouracil (MTU) with acidic potassium permanganate and the combination technique of high-performance liquid chromatography (HPLC), a se... |
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Influence of thiouracil-induced hypothyroidism on adrenal and gonadal functions in adult female rats.
J. Vet. Med. Sci. 60(4) , 439-46, (1998) The effect of hypothyroidism on adrenals and gonads in adult female rats was investigated throughout the estrous cycle. Hypothyroidism was induced by administration of 4-Methyl-2-Thiouracil (Thiouracil) in the drinking water. The weight of ovaries and adrenal... |
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In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil.
Eur. J. Biochem. 242(3) , 506-11, (1996) Regulation of annexin concentration and localization were investigated in thyroid tissues of hypothyroid [methylthiouracil (MeSur) treatment], euthyroid (control) and hyperthyroid [thyroxine (T4) treatment] rats. A low level of circulating thyroid hormones in... |
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Synthesis and biological activity of modified thiopyrimidine nucleosides.
Nucleosides Nucleotides 18(10) , 2307-15, (1999) N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were ev... |