Nucleosides & nucleotides 1999-10-01

Synthesis and biological activity of modified thiopyrimidine nucleosides.

A M Attia, M A Sallam, A A Almehdi, M M Abbasi

Index: Nucleosides Nucleotides 18(10) , 2307-15, (1999)

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Abstract

N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were evaluated for their inhibitory activity against Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well as for their cytotoxicity.