N-(2-Hydroxyethyl)piperazine
N-(2-Hydroxyethyl)piperazine structure
|
Common Name | N-(2-Hydroxyethyl)piperazine | ||
|---|---|---|---|---|
| CAS Number | 103-76-4 | Molecular Weight | 130.19 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 245.0±20.0 °C at 760 mmHg | |
| Molecular Formula | C6H14N2O | Melting Point | -38.5 °C | |
| MSDS | Chinese USA | Flash Point | 101.9±21.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Drug Des. Devel. Ther. 9 , 425-64, (2015) Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of ad... |
|
|
P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation.
Thromb. Haemost. 112(1) , 142-50, (2014) ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional res... |
|
|
Phenotyping of CYP450 in human liver microsomes using the cocktail approach.
Anal. Bioanal. Chem 406(20) , 4875-87, (2014) The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-spe... |
|
|
Dengue virus binding and replication by platelets.
Blood 126 , 378-85, (2015) Dengue virus (DENV) infection causes ∼200 million cases of severe flulike illness annually, escalating to life-threatening hemorrhagic fever or shock syndrome in ∼500,000. Although thrombocytopenia is typical of both mild and severe diseases, the mechanism tr... |
|
|
Renin–angiotensin system contributes to naive T-cell migration in vivo
Arch. Biochem. Biophys. 573 , 1-13, (2015) • Ang II gradient is formed from the peripheral blood to the spleen. • The Ang II gradient is important to promote naïve T-cell migration to the spleen. • Captopril, an ACE blocker, reduced CCL19 and CCL25 production in the spleen. |
|
|
Self-nanoemulsifying drug delivery systems for oral insulin delivery: in vitro and in vivo evaluations of enteric coating and drug loading.
Int. J. Pharm. 477(1-2) , 390-8, (2014) This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid comple... |
|
|
Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation.
Biol. Pharm. Bull. 38 , 1054-62, (2015) Due to health concerns about phthalate esters, the use of alternative plasticizers is being considered. Phthalate esters enhance skin sensitization to fluorescein isothiocyanate (FITC) in mouse models. We have demonstrated that phthalate esters stimulate tran... |
|
|
Surface levels of CD20 determine anti-CD20 antibodies mediated cell death in vitro.
PLoS ONE 9(11) , e111113, (2014) The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on cells expressing different levels of CD20 on surface. Cells that harbor low CD20 levels may resists against therapeutics response to CD20-specific antib... |
|
|
Cryptogenic stroke and small fiber neuropathy of unknown etiology in patients with alpha-galactosidase A -10T genotype.
Orphanet J. Rare Dis. 9 , 178, (2015) Fabry disease (FD) is a multisystemic disorder with typical neurological manifestations such as stroke and small fiber neuropathy (SFN), caused by mutations of the alpha-galactosidase A (GLA) gene. We analyzed 15 patients carrying the GLA haplotype -10C>T [rs... |
|
|
Cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cells in vitro.
Drug Deliv. 22 , 444-53, (2015) Although several studies have shown that chlorhexidine (Cx) has bactericidal activity and exerts toxic effects on periodontal tissues a few studies evaluated mechanisms to reduce its adverse effects maintaining the antimicrobial properties. Therefore, the aim... |