Archives of Biochemistry and Biophysics 2015-05-01

Renin–angiotensin system contributes to naive T-cell migration in vivo

J.L. Silva-Filho, M.C. Souza, M.G. Henriques, A. Morrot, W. Savino, C. Caruso-Neves, A.A.S. Pinheiro

Index: Arch. Biochem. Biophys. 573 , 1-13, (2015)

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Abstract

• Ang II gradient is formed from the peripheral blood to the spleen. • The Ang II gradient is important to promote naïve T-cell migration to the spleen. • Captopril, an ACE blocker, reduced CCL19 and CCL25 production in the spleen.