2,6-diaminotoluene
2,6-diaminotoluene structure
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Common Name | 2,6-diaminotoluene | ||
|---|---|---|---|---|
| CAS Number | 823-40-5 | Molecular Weight | 122.168 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 284.2±20.0 °C at 760 mmHg | |
| Molecular Formula | C7H10N2 | Melting Point | 104-106 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 148.3±21.3 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Warning | |
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Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate.
Med. Lav. 103(5) , 361-71, (2012) Despite its advantages over environmental monitoring, biological monitoring of exposure to 2,4-:2,6-toluene diisocyanate (TDI) mixtures is still underused. The present study was designed in order to evaluate the feasibility and reliability of biological monit... |
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Air exposure assessment of TDI and biological monitoring of TDA in urine in workers in polyurethane foam industry.
Occup. Environ. Med. 69(2) , 93-8, (2012) Toluene diisocyanate (TDI) is used in the manufacturing process of polyurethane (PU) foams and is a potent inducer of occupational asthma. The objective of this study was to evaluate the correlation between the exposure to total TDI (2,4- and 2,6-TDI) in air ... |
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Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate.
Int. Arch. Occup. Environ. Health 78(6) , 459-66, (2005) To develop a simple and sensitive GC-MS method for determining toluene-diamine (TDA) in urine and to apply the method for biological monitoring of workers exposed to toluene-diisocyanate (TDI).After acid hydrolysis of 0.1 ml of urine, diluted tenfold with wat... |
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LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate.
Toxicol. Lett. 134(1-3) , 259-64, (2002) To improve the biological monitoring method for 2,6- and 2,4-toluenediisocyanate (TDI) exposure, we developed a simple and rapid method for analysis of the corresponding urinary metabolites, 2,6- and 2,4-toluenediamine (TDA) using liquid chromatograph-mass sp... |
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Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate.
Mutat. Res. 654(2) , 108-13, (2008) The Syrian hamster embryo (SHE) cell transformation assay has traditionally been conducted with a feeder layer of X-ray irradiated cells to provide growth support to the target cells seeded in low numbers. The feeder layer of cells consists of X-ray irradiate... |
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Biological monitoring of TDI-derived amines in polyurethane foam production.
Occup. Med. (Lond.) 57(6) , 444-8, (2007) Toluene diisocyanate (TDI) is used in industry in the production of flexible polyurethane foam, commonly a mixture of the 2,4- and 2,6- isomers. The production process may lead to exposure to diisocyanates which are associated with respiratory disease. A meth... |
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Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes.
Mutat. Res. 608(1) , 88-96, (2006) 2,4-Diaminotoluene (2,4-DAT) is a liver carcinogen in rats and mice whereas 2,6-DAT is not. Both are genotoxic in vitro. Tests for mutations in transgenic mice, unscheduled DNA synthesis (UDS), DNA damage and enhancement of initiated foci in vivo have shown s... |
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Risk evaluation of occupational exposure to methylene dianiline and toluene diamine in polyurethane foam.
Hum. Exp. Toxicol. 24(12) , 655-62, (2005) Methylene diphenylisocyanate (MDI) and toluene diisocyanate (TDI) are widely used in industry to produce polyurethane foam products. Small amounts of methylenedianiline (MDA) and toluene diamine (TDA) are released during MDI and TDI polymerization and may be ... |
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[Assessment of the emission of volatile organic compounds from polyurethane foams].
Rocz. Panstw. Zakl. Hig. 55(2) , 181-5, (2004) The emission of 2,4- and 2,6-diaminotoluene, triethylenediamine, diethanolamine and other volatile organic compounds from polyurethane foams was examined in environmental chamber. Tested materials did not release of amines. The emission of total volatile orga... |
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Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.
Toxicol. Sci. 114(1) , 71-8, (2010) An important trend in current toxicology is the replacement, reduction, and refinement of the use of experimental animals (the 3R principle). We propose a model in which in vivo genotoxicity and short-term carcinogenicity assays are integrated with F344 gpt d... |