Doxepin hydrochloride
Doxepin hydrochloride structure
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Common Name | Doxepin hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1229-29-4 | Molecular Weight | 315.837 | |
| Density | N/A | Boiling Point | 413.3ºC at 760mmHg | |
| Molecular Formula | C19H22ClNO | Melting Point | 187-189°C | |
| MSDS | Chinese USA | Flash Point | 121.3ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.
Biochem. Pharmacol. 91(2) , 231-41, (2014) Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and sec... |
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Transbuccal delivery of doxepin: studies on permeation and histological investigation.
Int. J. Pharm. 477(1-2) , 650-4, (2014) According to previous studies reporting the anesthetic/analgesic action of oral topical doxepin administration, this study evaluated a model of buccal permeation to determine the depth of delivery of doxepin into excised porcine buccal mucosa following topica... |
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[Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study].
Prz. Lek. 69(8) , 624-6, (2012) Doxepin is a tricyclic antidepressant from the group of dibenzoxepines. Apart from the antidepressant effect, it has also the sedative and anxiolytic effect, so it is used in the treatment of anxiety disorder in the course of psychosis, organic diseases and a... |
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Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Pharmacol. Rep. 66(3) , 459-65, (2014) The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been pr... |
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Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation.
Colloids Surf. B Biointerfaces 103 , 558-65, (2013) Antidepressants have been considered by their analgesic activity in numerous studies, and specifically tricyclic antidepressants to possess the greatest efficacy. Imipramine and doxepin have been reported to exhibit local anaesthetic properties. In order to i... |
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FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.
Am. Fam. Physician 84(9) , 1-2, (2011)
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Electromembrane surrounded solid phase microextraction: a novel approach for efficient extraction from complicated matrices.
J. Chromatogr. A. 1280 , 16-22, (2013) In the present work, electromembrane surrounded solid phase microextraction (EM-SPME) is introduced for the first time. The organic liquid membrane, which consists of 2-nitrophenyl octyl ether (NPOE), was immobilized in the pores of a hollow fiber (HF) and th... |
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Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.
Sleep 34(10) , 1433-42, (2011) To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia.The study was a randomized, double-blind, parallel-group, placebo-controlled trial. Patients meeting DSM-IV-TR criteria for primary insomnia were rand... |
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Docking and MD study of histamine H4R based on the crystal structure of H1R.
J. Mol. Graph. Model. 39 , 1-12, (2013) Histamine H4 receptor (H4R), a member of histamine receptor family, which belongs to class A of G-protein coupled receptors (GPCRs), has been reported to play a critical role in histamine-induced chemotaxis in mast cells and eosinophils. Recently, the crystal... |
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Efficacy and safety of doxepin 6 mg in a four-week outpatient trial of elderly adults with chronic primary insomnia.
Sleep Med. 13(2) , 133-8, (2012) The efficacy and safety of doxepin (DXP), a histamine H(1) receptor antagonist, was evaluated in elderly adults with sleep maintenance insomnia.This was a randomized, double-blind, placebo-controlled outpatient trial. Elderly adults meeting DSM-IV-TR criteria... |