Triphosgene
Triphosgene structure
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Common Name | Triphosgene | ||
|---|---|---|---|---|
| CAS Number | 32315-10-9 | Molecular Weight | 296.748 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 204.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C3Cl6O3 | Melting Point | 79-83 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 53.3±26.3 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking.
Biomaterials 35(25) , 7239-47, (2014) Directing the controlled differentiation and tracking of stem cells is essential to achieve successful stem cell therapy. In this work, we describe a multi-modal (MR/optical) transfection agent (MTA) for efficient gene delivery and cell tracking of human mese... |
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Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.
Macromol. Biosci. 15(3) , 342-50, (2015) Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown t... |
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Ultrasound-Triggered Phase-Transition Cationic Nanodroplets for Enhanced Gene Delivery.
ACS Appl. Mater. Interfaces 7 , 13524-37, (2015) Ultrasound as an external stimulus for enhanced gene transfection represents a safe, noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an ultrasound-triggered phase-transition cationic nanodroplet based on a novel perfl... |
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Tumor-preferential sustained drug release enhances antitumor activity of block copolymer micelles.
J. Drug Target. 22(7) , 619-28, (2014) Nanoparticles are widely used as drug carriers for controlled, tumor-targeted delivery of various anticancer agents that have biopharmaceutical limitations such as water solubility and tissue permeability. Growing evidence suggests that nanoparticles not only... |
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Polyethylenimine derivate conjugated with RGD-TAT-NLS as a novel gene vector.
Biomed Mater Eng 24(6) , 1933-9, (2014) To solve the contradiction between the cell toxicity and transfection efficiency of polyethylenimine (PEI) derivate in non-viral gene therapy, a novel gene vector, P123-PEI-R18 was synthesized by using biodegradable PEI derivate conjugated with trifunctional ... |
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pH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma.
ACS Nano 8(8) , 8027-39, (2014) Hepatocellular carcinoma (HCC) has one of the worst prognoses for survival as it is poorly responsive to both conventional chemotherapy and mechanism-directed therapy. This results from a lack of therapeutic concentration in the tumor tissue coupled with the ... |
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The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin.
Biomaterials 62 , 176-87, (2015) Camptothecin (CPT) is a potent antitumor agent and functions via inhibiting the activity of topoisomerase I during DNA replication. However, the clinical application of CPT has been greatly hindered by its extremely poor solubility, the instability of its act... |
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Surface charge switching nanoparticles for magnetic resonance imaging.
Int. J. Pharm. 471(1-2) , 127-34, (2014) In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid ... |
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Complexation-Driven Mutarotation in Poly(L-proline) Block Copolypeptides.
Biomacromolecules 16 , 3686-93, (2015) Novel poly(L-lysine)-block-poly(L-proline) (PLL-b-PLP)-based materials with all PLP helical conformers, i.e., PLP II and the rare PLP I are here reported. Electrostatic supramolecular complexation of the adjacent cationic PLL with anionic molecules bearing DN... |
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Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: Synthesis, cytostatic and antioxidative activity
Eur. J. Med. Chem. 86 , 502-14, (2014) Novel primaquine semicarbazides 7a–l and ureas 9a–g with modified benzhydryl, trityl, phenyl or hydroxyalkyl substituents were prepared and evaluated for cytostatic and antioxidative activities. Two synthetic approaches for preparation of the title semicarbaz... |