diltiazem hydrochloride
diltiazem hydrochloride structure
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Common Name | diltiazem hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 33286-22-5 | Molecular Weight | 450.979 | |
| Density | 1.26g/cm3 | Boiling Point | 594.4ºC at 760mmHg | |
| Molecular Formula | C22H27ClN2O4S | Melting Point | 212-214 °C | |
| MSDS | Chinese USA | Flash Point | 313.3ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.
Drug Metab. Dispos. 43 , 1218-25, (2015) Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyld... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Formulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M.
Pak. J. Pharm. Sci. 26(4) , 653-63, (2013) The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different form... |
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Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.
PLoS ONE 10 , e0125731, (2015) Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms responsible,... |
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Cardiovascular effects of ethanol extract of Rubus chingii Hu (Rosaceae) in rats: an in vivo and in vitro approach.
J. Physiol. Pharmacol. 65(3) , 417-24, (2014) Rubus chingii Hu (Rosaceae) is an important traditional Chinese medicine that has been used to improve function of the kidney and treat excessive polyuria. However, the effects of Rubus chingii on the cardiovascular system and its pharmacological mechanisms o... |
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The role of fillers and sodium metabisulfite on drug release from aged polyox tablets.
Drug Dev. Ind. Pharm. 40(11) , 1451-8, (2014) Polyethylene oxides (PEOs) are extensively used to control the release rate of drugs from matrices. Unfortunately, polyox polymers are prone to oxidation under high temperature and relative humidity. The aim of this study was to investigate the effect of sodi... |
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Identification and characterization of mefloquine efficacy against JC virus in vitro.
Antimicrob. Agents Chemother. 53 , 1840-9, (2009) Progressive multifocal leukoencephalopathy (PML) is a rare but frequently fatal disease caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of some immunocompromised individuals. Currently, no effective antiviral treatment ... |
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Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.
Environ. Technol. 35(9-12) , 1055-63, (2014) The fate and removal of six selected endocrine disrupting compounds in a lab-scale anaerobic/aerobic (A/O) sequencing batch reactor (SBR), operating at 5 days, solids retention time (SRT) were investigated. A carbamazepine (CBZ), acetaminophen (ATP), diltiaze... |
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Clinical reasoning: A 68-year-old man with a first presentation of status epilepticus.
Neurology 82(14) , e116-21, (2014) A 64-year-old man with transfusion-dependent myelodysplastic syndrome (MDS), hypertension, chronic obstructive pulmonary disease, hypothyroidism, blindness from treated syphilitic chorioretinitis, and no prior seizure history presented in generalized status e... |