Acyclovir
Acyclovir structure
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Common Name | Acyclovir | ||
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| CAS Number | 59277-89-3 | Molecular Weight | 225.205 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 576.5±58.0 °C at 760 mmHg | |
| Molecular Formula | C8H11N5O3 | Melting Point | 256-257°C | |
| MSDS | Chinese USA | Flash Point | 302.4±32.3 °C | |
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Liquid chromatography tandem mass spectrometry quantitation of intracellular concentrations of ganciclovir and its phosphorylated forms.
Anal. Bioanal. Chem 407(12) , 3449-56, (2015) Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement ... |
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Comparison of in vitro release rates of acyclovir from cream formulations using vertical diffusion cells.
AAPS PharmSciTech 15(4) , 994-9, (2014) Acyclovir, indicated in the treatment of herpes labialis ("cold sores"), is formulated as semisolid topical dosage forms and marketed in numerous countries. Since the formulations of the various acyclovir products may differ from country to country, this stud... |
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Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.
Drug Metab. Dispos. 43(1) , 147-53, (2014) This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- an... |
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Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC-ESI-MS/MS.
Anal. Bioanal. Chem 406(22) , 5501-6, (2014) Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC-ESI-MS/MS is used to identify the phenolic components of the most po... |
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Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.
Anal. Bioanal. Chem 407(8) , 2073-84, (2015) A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue. Method developme... |
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Phospholipid vesicle-based permeation assay and EpiSkin® in assessment of drug therapies destined for skin administration.
J. Pharm. Sci. 104(3) , 1119-27, (2015) Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this stud... |
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Improved permeability of acyclovir: optimization of mucoadhesive liposomes using the phospholipid vesicle-based permeation assay.
J. Pharm. Sci. 103(2) , 661-8, (2014) The antiviral drug acyclovir (ACV) suffers from poor solubility both in lipophilic and hydrophilic environment, leading to low and highly variable bioavailability. To overcome these limitations, this study aimed at designing mucoadhesive ACV-containing liposo... |
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Preparation and evaluation of high dispersion stable nanocrystal formulation of poorly water-soluble compounds by using povacoat.
J. Pharm. Sci. 103(11) , 3772-81, (2014) In this study, we reported the application of Povacoat®, a hydrophilic polyvinylalcohol copolymer, as a dispersion stabilizer of nanoparticles of poorly water-soluble compounds. In addition, the influence of aggregation of the nanoparticles on their solubilit... |
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Rapid determination of lamivudine in human plasma by high-performance liquid chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 40-4, (2014) A simple and rapid high-performance liquid chromatographic method with spectrophotometric detection was developed for the determination of lamivudine in human plasma. Sample preparation was accomplished through protein precipitation with acetonitrile followed... |
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In vitroinhibition of herpes simplex virus type 1 replication byMentha suaveolensessential oil and its main component piperitenone oxide
Phytomedicine 21(6) , 857-65, (2014) Several essential oils exert in vitro activity against bacteria and viruses and, among these latter, herpes simplex virus type 1 (HSV-1) is known to develop resistance to commonly used antiviral agents. Thus, the effects of the essential oil derived from Ment... |