Fentanyl citrate
Fentanyl citrate structure
|
Common Name | Fentanyl citrate | ||
|---|---|---|---|---|
| CAS Number | 990-73-8 | Molecular Weight | 528.594 | |
| Density | N/A | Boiling Point | 466.2ºC at 760 mmHg | |
| Molecular Formula | C28H36N2O8 | Melting Point | 153-156°C | |
| MSDS | USA | Flash Point | 11 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.
Cell. Signal. 27 , 1799-806, (2015) G protein-coupled receptor desensitization is typically mediated by receptor phosphorylation by G protein-coupled receptor kinase (GRK) and subsequent arrestin binding; morphine, however, was previously found to activate a c-Jun N-terminal kinase (JNK)-depend... |
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The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.
J. Pharmacol. Sci. 126(3) , 264-73, (2014) Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying op... |
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MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs.
Toxicol. Appl. Pharmacol. 284(1) , 16-32, (2015) Multi-walled carbon nanotubes (MWCNTs) are an inhomogeneous group of nanomaterials that vary in lengths, shapes and types of metal contamination, which makes hazard evaluation difficult. Here we present a toxicogenomic analysis of female C57BL/6 mouse lungs f... |
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Remifentanil has a minimal direct effect on sinoatrial node pacemaker activity in the Guinea pig heart.
Anesth. Analg. 117(5) , 1072-7, (2013) Whereas remifentanil administration is associated with severe bradycardia, it has yet to be fully investigated whether the negative chronotropic action of remifentanil is mediated by its direct action on sinoatrial (SA) node pacemaker activity in the heart ve... |
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Nanocarriers and the delivered drug: effect interference due to intravenous administration.
Eur. J. Pharm. Sci. 63 , 96-102, (2014) Intravenously administered nanocarriers are widely studied to improve the delivery of various therapeutic agents. However, recent in vivo studies have demonstrated that intravenously administered nanocarriers that do not contain any drug may affect cardiovasc... |
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A sensitive and reliable test instrument to assess swimming in rats with spinal cord injury.
Behav. Brain Res. 291 , 172-83, (2015) For clinical translation of experimental spinal cord injury (SCI) research, evaluation of animal SCI models should include several sensorimotor functions. Validated and reliable assessment tools should be applicable to a wide range of injury severity. The BBB... |
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The Efficacy and Safety of the Novel Peripheral Analgesic Isovaline as an Adjuvant to Propofol for General Anesthesia and Conscious Sedation: A Proof-of-Principle Study in Mice.
Anesth. Analg. 121 , 1481-7, (2015) The combination of propofol and an opioid analgesic is widely used for procedural sedation, as well as total IV anesthesia. However, opioids produce respiratory depression, a primary cause of death due to these agents. We recently reported on the antinocicept... |
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Superselective intra-arterial umbilical cord blood administration to BM in experimental animals.
Bone Marrow Transplant. 49(12) , 1486-91, (2014) Umbilical cord blood (UCB) as a source of hematopoietic stem cells for transplantation is limited by the low number of cells and delayed engraftment. UCB cells are infused i.v. for transplantation, although only a proportion of the cells reach the BM. We inve... |
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Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.
PLoS ONE 9(5) , e97687, (2014) In vascular biology, endothelial KCa2.3 and KCa3.1 channels contribute to arterial blood pressure regulation by producing membrane hyperpolarization and smooth muscle relaxation. The role of KCa2.3 and KCa3.1 channels in the pulmonary circulation is not fully... |
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Intracranial pressure response after pharmacologic treatment of intracranial hypertension.
J. Trauma Acute Care Surg. 77(1) , 47-53; discussion 53, (2014) The accepted treatment of increased intracranial pressure (ICP) in patients experiencing severe traumatic brain injury is multimodal and algorithmic, obscuring individual effects of treatment. Using continuous vital signs monitoring, we sought to measure trea... |