blasticidin s hydrochloride
blasticidin s hydrochloride structure
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Common Name | blasticidin s hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 3513-03-9 | Molecular Weight | 458.90 | |
| Density | N/A | Boiling Point | 772.1ºC at 760 mmHg | |
| Molecular Formula | C17H27ClN8O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 420.8ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.
J. Inorg. Biochem. 127 , 73-8, (2013) Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. It is widely used to control rice blast by foliar applicati... |
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Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.
Proc. Natl. Acad. Sci. U. S. A. 110(30) , 12283-8, (2013) The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments... |
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Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006) Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating norm... |
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Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist.
J. Immunol. 184 , 5980-5987, (2010) Vi capsular polysaccharide is a major virulence determinant of the human typhoid- causing pathogen Salmonella typhi; it is absent in nontyphoidal Salmonella serovars. We show in this study that through its specific interaction with the membrane recognition co... |
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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
J. Biol. Chem. 286 , 403-9, (2011) Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5'-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents... |