PNAS 2006-09-05

Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.

Elizabeth J Meredith, Michelle J Holder, Anders Rosén, Adrian Drake Lee, Martin J S Dyer, Nicholas M Barnes, John Gordon

Index: Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006)

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Abstract

Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating normal lymphocytes and dividing malignant clones rapidly arrested on exposure to dopamine in the low (