3513-03-9

3513-03-9 structure

Name: blasticidin s hydrochloride
Chemical Name: (2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride
CAS Number: 3513-03-9
Molecular Formula: C₁₇H₂₇ClN₈O₅
Molecular Weight: 458.90
Catalog: Biochemical Inhibitor DNA damage DNA/RNA Synthesis inhibitor
Create Date: 2018-08-02 12:03:01
Modify Date: 2024-01-08 11:18:29
Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1].

Name	(2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride
Synonyms	MFCD02091640 Blasticidine S hydrochloride BlasticidinS,monohydrochloride (8CI) Blasticidin S hydrochloride

Description	Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Blasticidin S (BlaS) is a broad spectrum antibiotic and inhibits cell growth in prokaryotes, fungi, plants, and mammalian cells[1].
References	[1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398.

Boiling Point	772.1ºC at 760 mmHg
Molecular Formula	C₁₇H₂₇ClN₈O₅
Molecular Weight	458.90
Flash Point	420.8ºC
Exact Mass	458.17900
PSA	215.67000
LogP	1.05570
Storage condition	−20°C
Water Solubility	Soluble in water. Insoluble in organic solvents.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R28
Safety Phrases	28-36/37-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3