Sumatriptan succinate
Sumatriptan succinate structure
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Common Name | Sumatriptan succinate | ||
|---|---|---|---|---|
| CAS Number | 103628-48-4 | Molecular Weight | 341.426 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 497.7ºC at 760 mmHg | |
| Molecular Formula | C18H27N3O6S | Melting Point | 165-166°C | |
| MSDS | USA | Flash Point | 254.8ºC | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Multidrug toxicity involving sumatriptan.
J. Anal. Toxicol. 39(1) , 75-9, (2015) A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT(1B/1D) receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No signs... |
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Thermal and 31P-NMR studies to elucidate sumatriptan succinate entrapment behavior in phosphatidylcholine/cholesterol liposomes. Comparative 31P-NMR analysis on negatively and positively-charged liposomes.
Colloids Surf. B Biointerfaces 105 , 14-23, (2013) In this paper, two techniques, differential scanning calorimetry (DSC) and phosphorus nuclear magnetic resonance ((31)P-NMR), have been used to characterize sumatriptan succinate-loaded charged liposomes. To complete the results obtained by DSC a hot stage mi... |
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Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.
Mol. Med. Report. 12 , 1524-34, (2015) Wuzhuyu decoction is a traditional Chinese medicine used for the effective treatment of migraines, termed 'Jueyin headache', in China. However, there have been few investigations to clarify the composition of Wuzhuyu decoction for the treatment of migraines. ... |
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5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.
Comp. Biochem. Physiol. B Biochem. Mol. Biol. 164(2) , 117-23, (2013) The presence of distinct class of 5-HT receptors in the melanophores of tilapia (Oreochromis mossambicus) is reported. The cellular responses to 5-HT (5-hydroxytryptamine), 5-HT(1), and 5-HT(2), agonists on isolated scale melanophores were observed with regar... |
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Freeze drying: exploring potential in development of orodispersible tablets of sumatriptan succinate.
Drug Dev. Ind. Pharm. 41(3) , 398-405, (2015) The present investigation is aimed at development and characterization of sumatriptan succinate orodispersible tablets (ODTs) prepared by freeze drying technology. The tablet excipients were screened and the composition was optimized based on parameters which... |
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In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells.
Gene Ther. 22 , 947-59, (2015) Oncolytic viruses (OV) have broad potential as an adjuvant for the treatment of solid tumors. The present study addresses the feasibility of clinically applicable drugs to enhance the oncolytic potential of the OV Delta24-RGD in glioblastoma. In total, 446 dr... |
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Role of 5-HT1B/1Dreceptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats
Life Sci. 92(22) , 1046-54, (2013) Aims The present study analyzed the potential antinociceptive effect of the antimigraine drugs sumatriptan, dihydroergotamine or methysergide in rats submitted to the formalin test. Moreover, by using selective antagonists, the role of 5-HT1B/1D serotonergic ... |
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Formation of NDMA from ranitidine and sumatriptan: the role of pH.
Water Res. 47(2) , 802-10, (2013) N-nitrosodimethylamine (NDMA) is an emerging disinfection by-product (DBP) which can be formed via the chloramination of amine-based precursors. The formation of NDMA is mainly determined by the speciation of chloramines and the precursor amine groups, both o... |
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Two cases of cluster headache effectively treated with levetiracetam.
Funct. Neurol. 28(1) , 63-4, (2013)
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Aspirin for acute migraine headaches in adults.
J. Neurol. Neurosurg. Psychiatr. 84(5) , 585-6, (2013)
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