Life Sciences 2013-06-13

Role of 5-HT1B/1Dreceptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats

Beatriz Godínez-Chaparro, Francisco J. López-Santillán, Carlos F. Argüelles, Carlos M. Villalón, Vinicio Granados-Soto

Index: Life Sci. 92(22) , 1046-54, (2013)

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Abstract

Aims The present study analyzed the potential antinociceptive effect of the antimigraine drugs sumatriptan, dihydroergotamine or methysergide in rats submitted to the formalin test. Moreover, by using selective antagonists, the role of 5-HT1B/1D serotonergic receptors was investigated in the antinociception induced by these antimigraine drugs.