N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺

• 常用名: N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺
• 英文名: PD168393
• CAS号: 194423-15-9
• 分子量: 369.215
• 密度: 1.6±0.1 g/cm3
• 沸点: 571.1±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₃BrN₄O
• 熔点: 279℃
• 闪点: 299.2±30.1 °C

用途

PD168393是一个强的,不可逆转的EGFR抑制剂,IC50是0.7 nM.

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺名称

• 中文名: N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺
• 英文名: N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺生物活性

• 描述: PD168393是一个强的,不可逆转的EGFR抑制剂,IC50是0.7 nM.
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 癌症
• 靶点:

  EGFR:0.7 nM (IC50)

• 参考文献:

  [1]. Fry DW et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.

  [2]. Sun X et al. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget. 2015 Nov 3;6(34):35478-95.

  [3]. Li G et al. Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1. PLoS One. 2014 Sep 19;9(9):e106349.

  [4]. White KJ et al. Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation. J Invest Dermatol. 2011 Feb;131(2):435-42.

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 571.1±50.0 °C at 760 mmHg
• 熔点: 279℃
• 分子式: C₁₇H₁₃BrN₄O
• 分子量: 369.215
• 闪点: 299.2±30.1 °C
• 精确质量: 368.027252
• PSA: 70.40000
• LogP: 3.72
• InChIKey: HTUBKQUPEREOGA-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.744
• 储存条件: -20°C

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺安全信息

• 危险品运输编码: NONH for all modes of transport

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺英文别名

• 2-Propenamide (N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]
• nchembio866-comp2
• pd 168393
• 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
• N-{4-[(3-Bromophenyl)amino]-6-quinazolinyl}acrylamide
• PD168393