13754-56-8

• 常用中文名：盐酸二氧丙嗪
• 常用英文名：Dioxopromethazine
• CAS号：13754-56-8
• 分子式：C₁₇H₂₀N₂O₂S
• 分子量：316.418
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-09-07 16:51:33
• 更新时间：2024-01-09 14:07:04
• 抗组胺，抗平滑肌痉挛、镇咳。适用于镇咳，平喘。也适用于治疗荨麻疹及皮肤瘙痒症等。

名称

• 中文名: 盐酸二氧丙嗪
• 英文名: 1-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine
• 中文别名: 10-(2-二甲氨基-异丙基)吩噻嗪-5,5-二氧化物的盐酸盐; 二氧丙嗪
• 英文别名: UNII:6OOT1MR6XS; 9,9-Dioxypromethazin; 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide (9CI); 9,9-Dioxopromethazine; 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethyl-2-propanamine; Promethazine SS oxide; Dioxopromethazine; Promethazine 5,5-dioxide; Prothanon; 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine; 9,9-Dioxopromethazin; 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 478.5±34.0 °C at 760 mmHg
• 熔点: 127-129ºC
• 分子式: C₁₇H₂₀N₂O₂S
• 分子量: 316.418
• 闪点: 243.2±25.7 °C
• 精确质量: 316.124542
• PSA: 49.00000
• LogP: 2.18
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.606
• 储存条件: 室温

生物活性

• 描述: 二氧丙嗪是一种口服活性抗组胺药。二氧丙嗪抑制哮喘症状[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Bartsch R, et al. Zur Pharmakologie des neuen Antihistaminicums 9.9-Dioxopromethazin (Prothanon) [Pharmacology of the new antihistaminic 9,9-dioxopromethazine (Prothanon)]. Pharmazie. 1970;25(2):91-96.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SO7350000 CHEMICAL NAME : Phenothiazine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide, monohydrochloride CAS REGISTRY NUMBER : 13754-56-8 LAST UPDATED : 199503 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C17-H20-N2-O2-S.Cl-H MOLECULAR WEIGHT : 352.91 WISWESSER LINE NOTATION : T C666 BN ISWJ B3N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 96 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970