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| 中文名 | 茶苯海明 |
|---|---|
| 英文名 | dimenhydrinate |
| 中文别名 |
1,3-二甲基-8-氯-3,7-二氢-1H-嘌呤-2,6-二酮 N,N-二甲基-2-(二苯基甲氧基)乙胺
1,3-二甲基-8氯-3,7-二氢-1H-嘌呤,6二酮-N,N-二甲基-2-(二苯基甲氧基)乙胺盐 |
| 英文别名 |
faston
dromyl N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate 8-Chlor-1,3-dimethyl-3,7-dihydro-purin-2,6-dion,Verbindung mit (2-Benzhydryloxy-aethyl)-dimethyl-amin gravol epha EINECS 208-350-8 vomexa amosyt MFCD00054265 emedyl dramyl emes Dimenhydrinate 8-chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione,compound with (2-benzhydryloxy-ethyl)-dimethyl-amine Dimenhydrinase DiMate |
| 描述 | Dimenhydrinate是一种抗催吐剂, 和抗组胺剂, 用作晕车的补救措施。 |
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| 相关类别 |
| 沸点 | 343.7ºC at 760 mmHg |
|---|---|
| 熔点 | 102-107ºC |
| 分子式 | C24H28ClN5O3 |
| 分子量 | 469.96400 |
| 闪点 | 101.5ºC |
| 精确质量 | 469.18800 |
| PSA | 85.15000 |
| LogP | 2.96790 |
| 外观性状 | 结晶白色粉末 |
| 储存条件 | 2-8°C |
| 水溶解性 | Slightly soluble (0.1-1 g/100 mL at 22 ºC) |
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Section 1. Chemical Product and Company Identification Catalog Dimenhydrinate Common Name/DI127 Number(s). Trade Name 523-87-5
CAS# Manufacturer SPECTRUM CHEMICAL MFG. CORP.RTECSXH5082000 TSCATSCA 8(b) inventory: Dimenhydrinate Commercial Name(s)Not available. CI# Not available. Synonym8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. IN CASE OF EMERGENCY with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1); Anautine; Andramine; Aviomarin; Dimenhydrinate; Diphenhydramine 8-chlorotheophylline; Diphenhydrinate; Ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-, compd. with 8-chlorotheophylline; Gravinol Novamin; Novamine; Teodramin; O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate; Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline; 2-(Benzhydryloxy)-N,N-dimethylethylamine compd. with 8-chlorotheophylline; Chloranautine; 8-Chlorotheophylline, compd. with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1); Diamarin; Dramamin; Dramamine; Dramarin; Dramyl; Dromyl; Eldodram; Gravinol (antiemetic); Gravol; Menhydrinate; Neo-navigan; Permital; Supremal; Travelin; Travelmin; Vomex A; Xamamina Chemical NameTheophylline, 8-chloro-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1) Not available.CALL (310) 516-8000 Chemical Family Dimenhydrinate Chemical FormulaC17H21NO.C7H7ClN4O2 SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by Weight NameCAS # 1) Dimenhydrinate523-87-5100 Toxicological DataNot applicable. on Ingredients Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: Not available. Potential Chronic Health MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. Effects TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition. Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of shocks, of heat. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. of Various Substances Dimenhydrinate Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Special Remarks onMaterial in powder form, capable of creating a dust explosion. Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystalline powder.)OdorOdorless. TasteNot available. Molecular Weight469.96 g/mole ColorWhite. pH (1% soln/water)Not available. Not available. Boiling Point Melting Point102-107°C (215.6-224.6°F) Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Not available. Odor Threshold Water/Oil Dist. Coeff.Not available. Not available. Ionicity (in Water) Dispersion PropertiesNot available. Dimenhydrinate SolubilitySoluble in cold water. Freely soluble in alcohol. Soluble in chloroform , benzene. Insoluble in diethyl ether. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, dust generation, incompatible materials Incompatibility with variousReactive with oxidizing agents. substances CorrosivityNon-corrosive in presence of glass. Not available. Special Remarks on Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 1320 mg/kg [Rat]. Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onMay affect genetic material (mutagenic) Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May be harmul is swallowed. May cause dry mouth, adbominal distress vomiting, nausea, diarrhea or constipaton, anorexia. May affect behavior (central nervous system (drowsiness, lethargy, fatigue. excitement, hallucinations; hypnosis, convulsions, coma), cardiovascular system (cardiac arrhythmias). Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are as toxic as the product itself. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Dimenhydrinate Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT Classification Not a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms California prop. 65: This product contains the following ingredients for which the State of California has found Federal and State to cause birth defects which would require a warning under the statute: No products were found. Regulations TSCA 8(b) inventory: Dimenhydrinate CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 208-350-8). Canada: Listed on Canadian Domestic Substance List (DSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R22- Harmful if swallowed.S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) Dimenhydrinate TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302 |
| 警示性声明 | P301 + P312 + P330 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn:Harmful |
| 风险声明 (欧洲) | R22 |
| 安全声明 (欧洲) | 22-26-36/37/39-53 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | XH5082000 |
| 海关编码 | 2933990090 |
| 海关编码 | 2933990090 |
|---|---|
| 中文概述 | 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |