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瑞普特罗

瑞普特罗用途

雷公藤醇是一种双重作用的β2肾上腺素受体激动剂和PDE抑制剂。雷公藤醇的茶碱成分抑制腺苷酸环化酶诱导的磷酸二酯酶活性。雷普特罗有可能用于哮喘研究[1][2]。

瑞普特罗名称

[ CAS 号 ]:
54063-54-6

[ 中文名 ]:
瑞普特罗

[ 英文名 ]:
Reproterol

[英文别名 ]:

Reproterol [INN:BAN]
EINECS 258-956-1
Reproterolum [INN-Latin]
D 1959
Reproterol

瑞普特罗生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 炎症/免疫

[ 靶点 ]

β2 adrenoceptor

[参考文献]

[1]. Uwe R Juergens, et al. Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro. Eur J Med Res. 2004 Jul 30;9(7):365-70.

[2]. C G Georgakopoulos, et al. Excretion study of the beta2-agonist reproterol in human urine. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):141-8.

瑞普特罗物理化学性质

[ 密度 ]:
1.47g/cm3

[ 沸点 ]:
723.4ºC at 760mmHg

[ 分子式 ]:
C₁₈H₂₃N₅O₅

[ 分子量 ]:
389.41

[ 闪点 ]:
391.3ºC

[ 精确质量 ]:
389.17000

[ PSA ]:
134.54000

瑞普特罗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5098950

CHEMICAL NAME :: Theophylline, 7-(3-((2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)amino)p ropyl)-

CAS REGISTRY NUMBER :: 54063-54-6

BEILSTEIN REFERENCE NO. :: 0590567

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H23-N5-O5

MOLECULAR WEIGHT :: 389.46

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ B3N2QR CQ EQ& F1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,14,1977