原卟啉
原卟啉结构式
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常用名 | 原卟啉 | 英文名 | Protoporphyrin IX |
|---|---|---|---|---|
| CAS号 | 553-12-8 | 分子量 | 562.658 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 1122.0±65.0 °C at 760 mmHg | |
| 分子式 | C34H34N4O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 632.4±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.
Br. J. Cancer 111(5) , 874-82, (2014) Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of arsenic trioxide (ATO) with ATRA has emerged as an effectiv... |
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Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage.
Chem. Biol. Interact. 221 , 77-87, (2014) The clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with adverse effects in the kidney. Indomethacin, an NSAID that has been shown to induce oxidative stress in the kidney, was used to study the pathogenesis of renal damage ... |
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Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells.
Pharmazie 69(8) , 621-8, (2014) Protoporphyrin IX (PpIX) is an effective hematoporphyrin derivative, widely adopted in photodynamic therapy (PDT) and sonodynamic therapy (SDT). As a sensitizer, PpIX could significantly enhance laser light or ultrasound causing tumor cell damage in PDT/SDT s... |
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Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer-Linked Gold Quantum Clusters.
ACS Nano 9 , 5825-32, (2015) Fluorescence imaging assisted photodynamic therapy (PDT) is a viable two-in-one clinical tool for cancer treatment and follow-up. While the surface plasmon effect of gold nanorods and nanoparticles has been effective for cancer therapy, their emission propert... |
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The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese.
PLoS Genet. 11(3) , e1004977, (2015) Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer plus M... |
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Protein structure. Structure and activity of tryptophan-rich TSPO proteins.
Science 347(6221) , 551-5, (2015) Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich sequences that are highly conserved from bacteria to mammals. He... |
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Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Nat. Commun. 6 , 6750, (2015) During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates ... |
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Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.
PLoS ONE 9(12) , e115362, (2014) High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the exact functions of HtrA1 in these diseases remain poorly understood. We seek to unravel the mechanis... |
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Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro.
Antiviral Res. 110 , 60-9, (2014) Virus replication depends upon host-cell processes in infected cells, and this is true for porcine reproductive and respiratory syndrome virus (PRRSV), the causative agent of PRRS that is a worldwide threat to the swine industry. Heme oxygenase-1 (HO-1) is a ... |
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Functional characterization of the two ferrochelatases in Arabidopsis thaliana.
Plant Cell Environ. 38(2) , 280-98, (2015) The enzyme ferrochelatase catalyses the formation of protoheme by inserting Fe(2+) into protoporphyrin IX. Although most organisms express only one ferrochelatase, all land plants analysed so far possess at least two ferrochelatase proteins. Analysis of publi... |