5-(N-乙基-N-异丙基)阿米洛利
5-(N-乙基-N-异丙基)阿米洛利结构式
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常用名 | 5-(N-乙基-N-异丙基)阿米洛利 | 英文名 | EIPA |
|---|---|---|---|---|
| CAS号 | 1154-25-2 | 分子量 | 299.760 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 543.9±60.0 °C at 760 mmHg | |
| 分子式 | C11H18ClN7O | 熔点 | 202-205ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 282.8±32.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
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Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.
Am. J. Physiol. Renal Physiol. 307(11) , F1249-62, (2014) The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule. In response to a rise in blood pressure NHE3 redistributes in the ... |
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Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I.
Biosci. Biotechnol. Biochem. 79 , 1061-6, (2015) Amilorides, well-known inhibitors of Na(+)/H(+) antiporters, have also shown to inhibit bacterial and mitochondrial NADH-quinone oxidoreductase (complex I). Since the membrane subunits ND2, ND4, and ND5 of bovine mitochondrial complex I are homologous to Na(+... |
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Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis.
Nanoscale 8 , 6129-45, (2016) Nowadays, concern about the use of nanotechnology for biomedical application is unprecedentedly increasing. In fact, nanosystems applied for various potential clinical uses always have to cross the primary biological barrier consisting of epithelial cells. Ho... |
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SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.
PLoS ONE 10 , e0126576, (2015) The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-A plays an important role in pulmonary immunity by enhancing opsonization and clearance of pa... |
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Energy independent uptake and release of polystyrene nanoparticles in primary mammalian cell cultures.
Exp. Cell Res. 330(2) , 240-7, (2014) Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs ... |
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Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem cells.
ACS Nano 8(12) , 12151-66, (2014) Chemoresistance is a primary cause of treatment failure in cancer and a common property of tumor-initiating cancer stem cells. Overcoming mechanisms of chemoresistance, particularly in cancer stem cells, can markedly enhance cancer therapy and prevent recurre... |
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SLC4A11 is an EIPA-sensitive Na(+) permeable pHi regulator.
Am. J. Physiol. Cell Physiol. 305(7) , C716-27, (2013) Slc4a11, a member of the solute linked cotransporter 4 family that is comprised predominantly of bicarbonate transporters, was described as an electrogenic 2Na(+)-B(OH)4(-) (borate) cotransporter and a Na(+)-2OH(-) cotransporter. The goal of the current study... |
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Cellular uptake mechanism of TCTP-PTD in human lung carcinoma cells.
Mol. Pharm. 12(1) , 194-203, (2015) We reported previously that human translationally controlled tumor protein (TCTP) contains, at its NH2-terminus, a protein transduction domain (PTD), which we called TCTP-PTD, with the amino acid sequence MIIYRDLISH. In this report we describe how TCTP-PTD pe... |
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Entry of a novel marine DNA virus, Singapore grouper iridovirus, into host cells occurs via clathrin-mediated endocytosis and macropinocytosis in a pH-dependent manner.
J. Virol. 88(22) , 13047-63, (2014) Iridoviruses are nucleocytoplasmic DNA viruses which cause great economic losses in the aquaculture industry but also show significant threat to global biodiversity. However, a lack of host cells has resulted in poor progress in clarifying iridovirus behavior... |