1-甲基-1,2,3,4-四氢异喹啉
1-甲基-1,2,3,4-四氢异喹啉结构式
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常用名 | 1-甲基-1,2,3,4-四氢异喹啉 | 英文名 | 1-Methyl-1,2,3,4-tetrahydroisoquinoline |
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| CAS号 | 4965-09-7 | 分子量 | 147.217 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 239.3±9.0 °C at 760 mmHg | |
| 分子式 | C10H13N | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 100.0±14.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Comparative behavioral and neurochemical studies of R- and S-1-methyl-1,2,3,4-tetrahydroisoquinoline stereoisomers in the rat.
Pharmacol. Rep. 64(4) , 857-69, (2012) 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ) is present in human and mammalian brain as a racemate (R,S) of two stereoisomers: R- and S-1MeTIQ. The racemate is a mixture of the endogenous, synthesized in the brain dextrorotary R-1MeTIQ, and the exogenous... |
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Important role of 3-methoxytyramine in the inhibition of cocaine sensitization by 1-methyl-1,2,3,4-tetrahydroisoquinoline: an in vivo microdialysis study.
Pharmacol. Rep. 62(6) , 983-97, (2010) 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous compound with neuroprotective and antidopaminergic activities. Our previous research has shown that 1MeTIQ prevents morphine addiction and abates the expression of the reinstatement of cocaine ... |
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Determination method of 1-methyl-1,2,3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay.
Life Sci. 70(24) , 2871-83, (2002) To develop a sensitive and simple assay method for 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous parkinsonism-preventing substance, we designed two kinds of 1MeTIQ-bovine serum albumin (BSA) conjugates to recognize the methyl group at the 1 ... |
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Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: A type I isobolographic analysis
Epilepsy Res. 89(2-3) , 207-19, (2010) The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ—an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], o... |
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The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.
J. Neural Transm. Gen. Sect. 110(11) , 1205-13, (2003) To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morp... |
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A synthesis of heteroaromatic analogues of 1-methyl-1,2,3,4-tetrahydroisoquinoline using the Pummerer-type cyclization reaction: observation of tandem cyclization reaction.
Chem. Pharm. Bull. 52(2) , 214-20, (2004) The sulfoxides 7b and 7d carrying thiophene or benzothiophene as heteroaromatic nucleophiles, when treated with trifluoroacetic anhydride at room temperature (Pummerer reaction), underwent an intramolecular alkylation in an exclusive manner to yield 4,5,6,7-t... |
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Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat.
Brain Res. 955(1-2) , 161-3, (2002) 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), an endogenous monoamine, which prevents the neurotoxic effect of 1-methyl-4-phenylpyridinium ion (MPP(+)) and other endogenous neurotoxins, has been described as being enzymatically formed in the brain by the... |
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Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.
Brain Res. 1033(2) , 143-50, (2005) 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous brain amine and its content in parkinsonian brain is decreased compared with that in control brain. There is some evidence that 1MeTIQ protects dopaminergic neurons against dysfunction such as ... |
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Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone.
Int. J. Neuropsychopharmacol. 7(2) , 155-63, (2004) The aim of this paper was to investigate whether rotenone, a pesticide causing experimental parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally and whether this action may be prevented by peripheral administration of 1-m... |
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Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines.
ChemBioChem. 6(4) , 637-9, (2005)
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