5-氟尿嘧啶核苷
5-氟尿嘧啶核苷结构式
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常用名 | 5-氟尿嘧啶核苷 | 英文名 | 5-Fluorouridine |
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| CAS号 | 316-46-1 | 分子量 | 262.192 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C9H11FN2O6 | 熔点 | 182-184 °C | |
| MSDS | 美版 | 闪点 | N/A |
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Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
J. Pharm. Biomed. Anal. 110 , 58-66, (2015) 5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. Three intracellular formed metabolites are responsible for ... |
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N4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate)
Bioorg. Med. Chem. 19(11) , 3520-6, (2011) New cytostatic antimetabolite-bisphosphonates. |
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Evidence for Transcriptional Activity in the Syncytiotrophoblast of the Human Placenta
Placenta 30(4) , 329-34, (2009) The aim was to test for evidence of transcriptional activity within the nuclei of the syncytiotrophoblast of the human placenta. The syncytiotrophoblast forms the epithelial covering of the villous tree, and is a multinucleated, terminally-differentiated sync... |
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Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Plant Cell 23(8) , 2991-3006, (2011) Nucleotides are synthesized from de novo and salvage pathways. To characterize the uridine salvage pathway, two genes, UKL1 and UKL2, that tentatively encode uridine kinase (UK) and uracil phosphoribosyltransferase (UPRT) bifunctional enzymes were studied in ... |
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TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.
J. Struct. Biol. 167(3) , 235-41, (2009) TDP-43 is a RNA/DNA-binding protein structurally related to nuclear hnRNP proteins. Previous biochemical studies have shown that this nuclear protein plays a role in the regulation of gene transcription, alternative splicing and mRNA stability. Despite the ub... |
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The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another.
J. Am. Chem. Soc. 133(31) , 11826-9, (2011) The pseudouridine synthase TruB handles 5-fluorouridine in RNA as a substrate, converting it into two isomeric hydrated products. Unexpectedly, the two products differ not in the hydrated pyrimidine ring but in the pentose ring, which is epimerized to arabino... |
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Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.
Neurotox. Res. 17(2) , 167-78, (2010) The ubiquitin-dependent proteasome system (UPS) is the major pathway responsible for selective nuclear and cytoplasmic protein degradation. Bortezomib, a boronic acid dipeptide, is a reversible 20S proteasome inhibitor used as novel anticancer drug, particula... |
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Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Mol. Cancer Ther. 8(5) , 1037-44, (2009) 5-Fluorouracil (5-FU) continues to be widely used for treatment of gastrointestinal cancers. Because many tumors show primary or acquired resistance, it is important to understand the molecular basis underlying the mechanism of resistance to 5-FU. In addition... |
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Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Cancer Chemother. Pharmacol. 62(2) , 363-8, (2008) Although the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd), is being evaluated clinically, it must be combined with the cytidine deaminase inhibitor tetrahydrouridine (THU) to prevent rapid metabolism of FdCyd to the pharmacologically acti... |
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Novel and highly regioselective route for synthesis of 5-fluorouridine lipophilic ester derivatives by lipozyme TL IM.
J. Biotechnol. 129(4) , 689-95, (2007) For the first time, lipozyme TL IM, an inexpensive lipase from Thermomyces lanuginosa, was successfully applied to the regioselective synthesis of lipophilic 5-fluorouridine ester derivatives. The ESI-MS and (13)C NMR analysis confirmed that the end products ... |